Low-Molecular-Weight Methylcellulose-Based Thermo-reversible Gel/Pluronic Micelle Combination System for Local and Sustained Docetaxel Delivery
- Title
- Low-Molecular-Weight Methylcellulose-Based Thermo-reversible Gel/Pluronic Micelle Combination System for Local and Sustained Docetaxel Delivery
- Other Titles
- Pluronic Micelle Combination System for Local and Sustained Docetaxel Delivery
- Author
- 김용희
- Keywords
- cancer therapy; docetaxel; drug delivery; gel/micelle combination system; methylcellulose
- Issue Date
- 2012-02
- Publisher
- Springer
- Citation
- Pharmaceutical Research., Feb 2012, 29(2), P.525-534
- Abstract
- To develop low-molecular-weight methylcellulose (LMw MC)-based gel/Pluronic F127 micelle combination system for local and sustained delivery of docetaxel (DTX).LMw MC and Pluronic F127 were used to formulate an injectable thermo-reversible gel/micelle combination system containing DTX. The DTX-loaded combination system was characterized and its therapeutic efficacy evaluated in a subcutaneous tumor model.Mixtures of LMw MC, AS, and Pluronic F127 formed gel at similar to 15-40A degrees C depending on AS concentration. The combination system released DTX for > 30 days with a biphasic and sustained release pattern, and DTX stability was maintained during release. The combination system significantly enhanced anti-cancer effects of DTX and prolonged survival of the model mouse in comparison with free DTX.The LMw MC gel/Pluronic F127 micelle combination system constitutes a promising tool for reducing tumor size and eradicating remaining tumor cells before and after surgery.
- URI
- https://link.springer.com/article/10.1007%2Fs11095-011-0581-8
- ISSN
- 0724-8741; 1573-904X
- DOI
- 10.1007/s11095-011-0581-8
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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