Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김정목 | - |
dc.date.accessioned | 2018-02-22T03:06:05Z | - |
dc.date.available | 2018-02-22T03:06:05Z | - |
dc.date.issued | 2012-07 | - |
dc.identifier.citation | The Journal of Nutritional Biochemistry, Volume 23, Issue 7, July 2012, Pages 759-767 | en_US |
dc.identifier.issn | 0955-2863 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0955286311001252 | - |
dc.description.abstract | Licochalcone E (lico E) is a retrochalcone isolated from the root of Glycyrrhiza inflata. Retrochalcone compounds evidence a variety of pharmacological profiles, including anticancer, antiparasitic, antibacterial, antioxidative and superoxide-scavenging properties. In this study, we evaluated the biological effects of lico E on adipocyte differentiation in vitro and obesity-related diabetes in vivo. We employed 3T3-L1 preadipocyte and C3H10T1/2 stem cells for in vitro adipocyte differentiation study and diet-induced diabetic mice for in vivo study. The presence of lico E during adipogenesis induced adipocyte differentiation to a significant degree, particularly at the early induction stage. Licochalcone E evidenced weak, but significant, peroxisome proliferator-activated receptor gamma (PPAR gamma) ligand-binding activity. Two weeks of lico E treatment lowered blood glucose levels and serum triglyceride levels in the diabetic mice. Additionally, treatment with lico E resulted in marked reductions in adipocyte size and increases in the mRNA expression levels of PPAR gamma in white adipose tissue (WAT). Licochalcone E was also shown to significantly stimulate Akt signaling in epididymal WAT. In conclusion, lico E increases the levels of PPAR gamma expression, at least in part, via the stimulation of Akt signals and functions as a PPAR gamma partial agonist, and this increased PPAR gamma expression enhances adipocyte differentiation and increases the population of small adipocytes, resulting in improvements in hyperglycemia and hyperlipidemia under diabetic conditions. (C) 2012 Elsevier Inc. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by the Priority Research Centers Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2010-0029702). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | LicochalconeE | en_US |
dc.subject | Adipocyte differentiation | en_US |
dc.subject | Obesity | en_US |
dc.subject | Diabetes | en_US |
dc.title | Licochalcone E has an antidiabetic effect. | en_US |
dc.type | Article | en_US |
dc.relation.no | 7 | - |
dc.relation.volume | 23 | - |
dc.identifier.doi | 10.1016/j.jnutbio.2011.03.021 | - |
dc.relation.page | 759-767 | - |
dc.relation.journal | JOURNAL OF NUTRITIONAL BIOCHEMISTRY | - |
dc.contributor.googleauthor | Park, Hong Gyu | - |
dc.contributor.googleauthor | Bak, Eun Jung | - |
dc.contributor.googleauthor | Woo, Gye-Hyeong | - |
dc.contributor.googleauthor | Kim, Jin Moon | - |
dc.contributor.googleauthor | Quan, Zhejiu | - |
dc.contributor.googleauthor | Kim, Jung Mogg | - |
dc.contributor.googleauthor | Yoon, Ho-Kun | - |
dc.contributor.googleauthor | Cheon, Seung Hoon | - |
dc.contributor.googleauthor | Yoon, Goo, | - |
dc.contributor.googleauthor | Yoo, Yun-Jung | - |
dc.relation.code | 2012205543 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jungmogg | - |
dc.identifier.orcid | http://orcid.org/0000-0002-6506-7519 | - |
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