염증성 장질환 환자에서 Azathioprine 사용방법에 따른 골수억제 부작용의 빈도
- Title
- 염증성 장질환 환자에서 Azathioprine 사용방법에 따른 골수억제 부작용의 빈도
- Other Titles
- Frequency of Bone Marrow Toxicity by Using Pattern of Azathioprine in Inflammatory Bowel Disease Patients
- Author
- 은창수
- Keywords
- Inflammatory Bowel Diseases; Azathioprine; Bone Marrow Toxicity
- Issue Date
- 2012-07
- Publisher
- 대한장연구학회
- Citation
- Intestinal research (Intest Res), Vol. 10, No. 3 (2012), pg. 244, 7 p.
- Abstract
- Background/AimsThe most important adverse effect of azathioprine (AZA) is bone marrow toxicity (BMT). Many physicians have preferred a gradual dose increment (GDI) policy for the prevention of BMT. The aim of this study was to evaluate the efficacy of GDI for the prevention of AZA-induced BMT in inflammatory bowel disease (IBD) patients.MethodsThe medical records of IBD patients who received AZA in 6 university hospitals were reviewed. The patients were divided into two groups: the GDI group (initial dose <1.5 mg/kg, gradually increased to a therapeutic dose) and the non-GDI group (initial therapeutic dose ≥2 mg/kg).ResultsA total of 308 patients were enrolled (male to female ratio, 1:2.3; mean age, 34.91±14.19 years; ulcerative colitis, 43.5%; Crohn's disease, 55.2%; and intermediate colitis, 1.3%). The overall incidence of BMT was 16.2% (50/308). BMT developed most frequently between fourth to eighth week (26%, 13/50). The rate of BMT of the non-GDI group was significantly higher than that of the GDI group (27.5%, 11/40 vs. 14.6%, 39/268, P=0.038). A multivariate analysis showed that the only factor related to BMT was a non-GDI policy (P=0.036; odds ratio, 2.41; 95% confidence interval, 1.06-5.49).ConclusionsA GDI policy could be useful for reducing AZA-induced BMT in Korean IBD patients.
- URI
- http://kiss.kstudy.com/thesis/thesis-view.asp?key=3374462http://hdl.handle.net/20.500.11754/38046
- ISSN
- 1598-9100
- DOI
- 10.5217/ir.2012.10.3.244
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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