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dc.contributor.author김동욱-
dc.date.accessioned2018-02-19T00:05:46Z-
dc.date.available2018-02-19T00:05:46Z-
dc.date.issued2015-08-
dc.identifier.citationELIFE, v. 4, Article ID. e7335en_US
dc.identifier.issn2050-084X-
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522646/-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/37960-
dc.description.abstractShigella flexneri is the most common cause of bacterial dysentery in low-income countries. Despite this, S. flexneri remains largely unexplored from a genomic standpoint and is still described using a vocabulary based on serotyping reactions developed over half-a-century ago. Here we combine whole genome sequencing with geographical and temporal data to examine the natural history of the species. Our analysis subdivides S. flexneri into seven phylogenetic groups (PGs); each containing two-or-more serotypes and characterised by distinct virulence gene complement and geographic range. Within the S. flexneri PGs we identify geographically restricted sub-lineages that appear to have persistently colonised regions for many decades to over 100 years. Although we found abundant evidence of antimicrobial resistance (AMR) determinant acquisition, our dataset shows no evidence of subsequent intercontinental spread of antimicrobial resistant strains. The pattern of colonisation and AMR gene acquisition suggest that S. flexneri has a distinct life-cycle involving local persistence. DOI: 10.7554/eLife.07335.001en_US
dc.language.isoen_USen_US
dc.publisherELIFE SCIENCES PUBLICATIONS LTDen_US
dc.subjectO-ANTIGEN MODIFICATIONen_US
dc.subjectESCHERICHIA-COLIen_US
dc.subjectSALMONELLA-TYPHIMURIUMen_US
dc.subjectPATHOGENICITY ISLANDen_US
dc.subjectENTERIC MULTICENTERen_US
dc.subjectVACCINE DEVELOPMENTen_US
dc.subjectASIAN COUNTRIESen_US
dc.subjectYOUNG-CHILDRENen_US
dc.subjectBAPS SOFTWAREen_US
dc.subjectIN-VITROen_US
dc.titleSpecies-wide whole genome sequencing reveals historical global spread and recent local persistence in Shigella flexnerien_US
dc.typeArticleen_US
dc.relation.volume4-
dc.identifier.doi10.7554/eLife.07335-
dc.relation.page7335-7335-
dc.relation.journalELIFE-
dc.contributor.googleauthorConnor, TR-
dc.contributor.googleauthorBarker, CR-
dc.contributor.googleauthorBaker, KS-
dc.contributor.googleauthorWeill, FX-
dc.contributor.googleauthorTalukder, KA-
dc.contributor.googleauthorSmith, AM-
dc.contributor.googleauthorBaker, S-
dc.contributor.googleauthorGouali, M-
dc.contributor.googleauthorThanh, DP-
dc.contributor.googleauthorKim, DW-
dc.contributor.googleauthorAzmi, IJ-
dc.contributor.googleauthorda Silveira, WD-
dc.contributor.googleauthorSemmler, T-
dc.contributor.googleauthorWieler, LH-
dc.contributor.googleauthorJenkins, C-
dc.contributor.googleauthorCravioto, A-
dc.contributor.googleauthorFaruque, SM-
dc.contributor.googleauthorParkhill, J-
dc.contributor.googleauthorKeddy, KH-
dc.contributor.googleauthorThomson, NR-
dc.relation.code2015012574-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.piddongwook-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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