Successful Treatment of Cutaneous Lesions of Dermatomyositis with Topical Pimecrolimus
- Title
- Successful Treatment of Cutaneous Lesions of Dermatomyositis with Topical Pimecrolimus
- Author
- 노영석
- Keywords
- Dermatomyositis; Pimecrolimus; TACROLIMUS
- Issue Date
- 2011-08
- Publisher
- KOREAN DERMATOLOGICAL ASSOC, 305 SEOCHO NASAN, SUITE OFFICE 1330-16, SEOCHO-2-DONG, SEOCHO-GU, SEOUL, 137-858, SOUTH KOREA
- Citation
- Annals of Dermatology, Vol.23 No.3 [2011], 348-351
- Abstract
- Dermatomyositis (DM) is an idiopathic inflammatory process characterized by proximal muscle weakness and cutaneous lesions, such as the Gottron's sign, heliotrope rash, and erythematous photosensitive. rash. Administration of systemic agents for the treatment of underlying systemic diseases leads to remission of the cutaneous lesions in many cases. However, cutaneous lesions may remain refractory to treatment. Pimecrolimus is a calcineurin inhibitor with combined anti-inflammatory and immunomodulatory activity. It has high affinity to the skin and low permeation potential, even in patients with acute skin inflammation and in those undergoing post-topical corticosteroid therapy. We herein report two DM patients whose cutaneous lesions were refractory to conventional treatment but showed dramatic response to topical pimecrolimus. The clinical outcomes suggest that topical pimecrolimus may be a good therapeutic alternative for the management of the cutaneous lesions of DM. (Ann Dermatol 23(3) 348 similar to 351, 2011)
- URI
- https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001575041https://synapse.koreamed.org/DOIx.php?id=10.5021/ad.2011.23.3.348
- ISSN
- 1013-9087
- DOI
- 10.5021/ad.2011.23.3.348
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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