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dc.contributor.author정승준-
dc.date.accessioned2018-02-14T07:54:18Z-
dc.date.available2018-02-14T07:54:18Z-
dc.date.issued2012-04-
dc.identifier.citationExp Neurobiol, 21, 2, 68-74en_US
dc.identifier.issn1226-2560-
dc.identifier.urihttps://synapse.koreamed.org/DOIx.php?id=10.5607/en.2012.21.2.68-
dc.description.abstractThe long belief that dental primary afferent (DPA) neurons are entirely composed of nociceptive neurons has been challenged by several anatomical and functional investigations. In order to characterize non-nociceptivepopulation among DPA neurons, retrograde transport fluorescent dye was placed in upper molars of rats and immunohistochemical detection of peripherin and neurofilament 200 in the labeled trigeminal ganglia was performed. As the results, majority ofDPA neurons were peripherin-expressing small-sized neurons, showing characteristic ofnociceptive C-fibers. However, 25.7% of DPA were stained with antibody against neurofilament 200, indicating significant portion of DPA neurons are related to large myelinated Aβ fibers. There were a small number of neurons thatexpressed both peripherin and neurofilament 200, suggestive of Aδ fibers. The possible transition of neurochemical properties by neuronal injury induced by retrograde labeling technique was ruled out by detection of minimal expression of neuronal injury marker, ATF-3. These results suggest that in addition to the large population of C-fiber-related nociceptive neurons, a subset of DPA neurons is myelinated large neurons, which is related to low-threshold mechanosensitive Aβ fibers. We suggest that these Aβ fiber-related neurons might play a role as mechanotransducers of fluid movement within dentinal tubules.en_US
dc.description.sponsorshipThis work was supported by grant (2011-0028233) from the Medical Research Center Program and grant (2011-0018614) from National Research Laboratory Program, funded by the Ministry of Education, Science and Technology, the Republic of Korea. Th ere is no confl ict of interest.en_US
dc.language.isoenen_US
dc.publisher한국뇌신경과학회en_US
dc.subjectnociceptoren_US
dc.subjecttrigeminal ganglionen_US
dc.subjecttooth painen_US
dc.subjectperipherinen_US
dc.subjectNF200en_US
dc.subjectATF3en_US
dc.titleNeurochemical properties of dental primary afferent neurons.en_US
dc.typeArticleen_US
dc.relation.no2-
dc.relation.volume21-
dc.identifier.doi10.5607/en.2012.21.2.68-
dc.relation.page68-74-
dc.relation.journalEXPERIMENTAL NEUROBIOLOGY-
dc.contributor.googleauthorVang, Hue-
dc.contributor.googleauthorChung, Gehoon-
dc.contributor.googleauthorKim, Hyun Yeong-
dc.contributor.googleauthorPark, Seok-Beom-
dc.contributor.googleauthorJung, Sung Jun-
dc.contributor.googleauthorKim, Joong-Soo-
dc.contributor.googleauthorOh, Seog Bae-
dc.relation.code2012232721-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pideurijj-


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