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Solid self-nanoemulsifying drug delivery system (SNEDDS) for enhanced oral bioavailability of poorly water-soluble tacrolimus: physicochemical characterisation and pharmacokinetics

Title
Solid self-nanoemulsifying drug delivery system (SNEDDS) for enhanced oral bioavailability of poorly water-soluble tacrolimus: physicochemical characterisation and pharmacokinetics
Author
최한곤
Keywords
Bioavailability; colloidal silica; self-nanoemulsifying drug delivery system; solid carrier; tacrolimus; SPRAY-DRYING TECHNIQUE; ORGAN-TRANSPLANTATION; DISPERSION; SOLUBILITY; EMULSIFICATION; DISSOLUTION; SUSPENSION; STABILITY; UPDATE; DOGS
Issue Date
2015-08
Publisher
TAYLOR & FRANCIS LTD
Citation
JOURNAL OF MICROENCAPSULATION, v. 32, No. 5, Page. 503-510
Abstract
To develop a novel self-nanoemulsifying drug delivery system (solid SNEDDS) with better oral bioavailability of tacrolimus, the solid SNEDDS was obtained by spray-drying the solutions containing the liquid SNEDDS and colloidal silica. Its reconstitution properties were determined and correlated to solid state characterisation of the powder. Moreover, the dissolution and pharmacokinetics in rats was done in comparison to the commercial product. Among the liquid SNEDDS formulations tested, the liquid SNEDDS comprised of Capryol PGMC, Transcutol HP and Labrasol (10: 15: 75, v/v/v) presented the highest dissolution rate. In the solid SNEDDS, this liquid SNEDDS was absorbed in the pores and attached onto the surface of the colloidal silica. Drug was present in the amorphous state in it. The solid SNEDDS with 5% w/v tacrolimus produced the nanoemulsions and improved the oral bioavailability of tacrolimus in rats. Therefore, this solid SNEDDS would be a potential candidate for enhancing the oral bioavailability of tacrolimus.
URI
http://www.tandfonline.com/doi/abs/10.3109/02652048.2015.1057252http://hdl.handle.net/20.500.11754/37429
ISSN
0265-2048; 1464-5246
DOI
10.3109/02652048.2015.1057252
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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