101 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author최재훈-
dc.date.accessioned2018-02-14T04:55:08Z-
dc.date.available2018-02-14T04:55:08Z-
dc.date.issued2011-09-
dc.identifier.citationCIRCULATION RESEARCH, Vol.109, No.7 [2011], p739-U80en_US
dc.identifier.issn0009-7330-
dc.identifier.urihttp://circres.ahajournals.org/content/109/7/739-
dc.description.abstractRationale: Peroxiredoxin 2 (Prdx2), a thiol-specific peroxidase, has been reported to regulate proinflammatory responses, vascular remodeling, and global oxidative stress.Objective: Although Prdx2 has been proposed to retard atherosclerosis development, no direct evidence and mechanisms have been reported.Methods and Results: We show that Prdx2 is highly expressed in endothelial and immune cells in atherosclerotic lesions and blocked the increase of endogenous H(2)O(2) by atherogenic stimulation. Deficiency of Prdx2 in apolipoprotein E-deficient (ApoE (-/-)) mice accelerated plaque formation with enhanced activation of p65, c-Jun, JNKs, and p38 mitogen-activated protein kinase; and these proatherogenic effects of Prdx2 deficiency were rescued by administration of the antioxidant ebselen. In bone marrow transplantation experiments, we found that Prdx2 has a major role in inhibiting atherogenic responses in both vascular and immune cells. Prdx2 deficiency resulted in increased expression of vascular adhesion molecule-1, intercellular adhesion molecule-1, and monocyte chemotactic protein-1, which led to increased immune cell adhesion and infiltration into the aortic intima. Compared with deficiency of glutathione peroxidase 1 or catalase, Prdx2 deficiency showed a severe predisposition to develop atherosclerosis.Conclusions: Prdx2 is a specific peroxidase that inhibits atherogenic responses in vascular and inflammatory cells, and specific activation of Prdx2 may be an effective means of antiatherogenic therapy. (Circ Res. 2011; 109: 739-749.)en_US
dc.description.sponsorshipThe authors are grateful to Dr Sun Hee Yim for critical comments and Dr Eun-Kyung Suh for reviewing the English.en_US
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINS, 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USAen_US
dc.subjectperoxiredoxin 2en_US
dc.subjectatherosclerosisen_US
dc.subjectinflammationen_US
dc.titlePeroxiredoxin 2 Deficiency Exacerbates Atherosclerosis in Apolipoprotein E-Deficient Miceen_US
dc.typeArticleen_US
dc.relation.no7-
dc.relation.volume109-
dc.identifier.doi10.1161/CIRCRESAHA.111.245530-
dc.relation.page739-80-
dc.relation.journalCIRCULATION RESEARCH-
dc.contributor.googleauthorPark, Jong-Gi-
dc.contributor.googleauthorYoo, Ji-Young-
dc.contributor.googleauthorJeong, Se-Jin-
dc.contributor.googleauthorLee, Mi-Ran-
dc.contributor.googleauthorLee, Mi-Ni-
dc.contributor.googleauthorLee, Jeong-Hwa-
dc.contributor.googleauthorKang, Sang-Won-
dc.contributor.googleauthorRhee, Sue-Goo-
dc.contributor.googleauthorOh, Goo-Taeg-
dc.contributor.googleauthorChoi, Jae-Hoon-
dc.relation.code2011201935-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF NATURAL SCIENCES[S]-
dc.sector.departmentDEPARTMENT OF LIFE SCIENCE-
dc.identifier.pidjchoi75-
dc.identifier.researcherID55794843400-
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE