Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 박용수 | - |
dc.date.accessioned | 2018-02-14T04:42:57Z | - |
dc.date.available | 2018-02-14T04:42:57Z | - |
dc.date.issued | 2011-11 | - |
dc.identifier.citation | Diabetes/Metabolism Research and Reviews, NOV 2011, 27 8, P975-979 | en_US |
dc.identifier.issn | 1520-7552 | - |
dc.identifier.issn | 1096-9837 | - |
dc.identifier.uri | http://onlinelibrary.wiley.com/doi/10.1002/dmrr.1278/abstract | - |
dc.description.abstract | Background Latent autoimmune diabetes in adults (LADA) is a form of autoimmune-mediated diabetes in adults, usually defined by GAD autoantibody positivity. Few epidemiological surveys on LADA in Asians did not come to a conclusive answer regarding prevalence and incidence, because of different criteria used in patient ascertainment.Methods We estimated LADA prevalence in a recent type 2 diabetes cohort by the positivity of circulating autoantibodies to pancreatic islet cell antigens (GAD, IA-2 and zinc transporter 8 (ZnT8)) applying a comparable Caucasian criteria. We then observed the development of insulin dependency prospectively for 36 months.Results Applying the European NIRAD LADA group criteria, we found a high prevalence of LADA (4.4%) in Korean patients with phenotypic type 2 diabetes. This high prevalence of LADA in Korea is noteworthy since the previous population-based LADA prevalence survey reported low prevalence (1.7%). When we consider the low-titre GAD antibodies and the low prevalence of multiple autoantibodies, however, increased LADA prevalence does not necessarily mean increase in future insulin dependency. After 36 months of follow-up, only 3 of 39 patients who were initially classified as LADA have become insulin-dependent. Those three were all positive for multiple autoantibodies (GAD, IA-2 and zinc transporter 8 antibody). Other features of insulin secretion or insulin resistance did not determine future insulin necessity.Conclusions Although the LADA prevalence estimated by anti-GAD positivity appeared to increase, the true insulin dependency evidenced by multiple antibody positivity did not increase in Korea. Copyright (C) 2011 John Wiley & Sons, Ltd. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley-Blackwell | en_US |
dc.subject | LADA | en_US |
dc.subject | prevalence | en_US |
dc.subject | incidence | en_US |
dc.subject | insulin dependency | en_US |
dc.subject | multiple autoantibody positivity | en_US |
dc.title | LADA prevalence estimation and insulin dependency during follow-up | en_US |
dc.type | Article | en_US |
dc.relation.volume | 27 | - |
dc.identifier.doi | 10.1002/dmrr.1278 | - |
dc.relation.page | 975-979 | - |
dc.relation.journal | DIABETES-METABOLISM RESEARCH AND REVIEWS | - |
dc.contributor.googleauthor | Park, Yongsoo | - |
dc.contributor.googleauthor | Hong, Sangmo | - |
dc.contributor.googleauthor | Park, Leejin | - |
dc.contributor.googleauthor | Woo, Jungtaek | - |
dc.contributor.googleauthor | Kim, Youngseol | - |
dc.contributor.googleauthor | Baik, Sehyun | - |
dc.contributor.googleauthor | Nam, Munsuk | - |
dc.contributor.googleauthor | Lee, Kwanwoo | - |
dc.contributor.googleauthor | 박용수 | - |
dc.contributor.googleauthor | 홍상모 | - |
dc.contributor.googleauthor | 박이진 | - |
dc.contributor.googleauthor | 우정택 | - |
dc.contributor.googleauthor | 김영설 | - |
dc.contributor.googleauthor | 백세현 | - |
dc.contributor.googleauthor | 남문숙 | - |
dc.contributor.googleauthor | 이관우 | - |
dc.relation.code | 2011202561 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | parkys | - |
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