Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 류성언 | - |
dc.date.accessioned | 2018-02-13T08:21:30Z | - |
dc.date.available | 2018-02-13T08:21:30Z | - |
dc.date.issued | 2011-11 | - |
dc.identifier.citation | Federation of European Biochemical Societies., JAN 3 2011, 585 1, P153-158 | en_US |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://febs.onlinelibrary.wiley.com/doi/abs/10.1016/j.febslet.2010.11.028 | - |
dc.description.abstract | The L1CAM antibody A10-A3 efficiently reduces tumor growth in a nude mouse model. Here, we describe the crystal structure of the Fab fragment of A10-A3 determined at 2.0 angstrom resolution. The A10-A3 antibody H3 loop reveals a characteristic arrangement of exposed aromatic residues that may play an important role in antigen binding. A structure model of the complex between L1CAM Ig1-4 and A10-A3 Fab indicates that the Fab binds to three small loops outside Ig1 and a residue between Ig1 and Ig2, consistent with an epitope mapping result. The data presented here should contribute to the design of high-affinity antibody for therapeutic purposes as well as to the understanding of neural cell remodeling and cancer progression mechanism mediated by L1CAM. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by a Hanyang University faculty Grant, a Ministry of Science and Technology (Korea) Grant (C1007150-01-01), a Kangwon National University Grant, a KRIBB research initiatives grant and a high field NMR Research Program of KBSI. We thank Dr. K.J. Kim (PAL BL6C) and staffs for help with data collection. | en_US |
dc.language.iso | en | en_US |
dc.publisher | FEBS LETTERS | en_US |
dc.subject | Crystal structure | en_US |
dc.subject | Antibody | en_US |
dc.subject | A10-A3 | en_US |
dc.subject | L1CAM | en_US |
dc.subject | Cancer | en_US |
dc.title | Structural mechanism of the antigen recognition by the L1 cell adhesion molecule antibody A10-A3 | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 585 | - |
dc.identifier.doi | 10.1016/j.febslet.2010.11.028 | - |
dc.relation.page | 153-158 | - |
dc.relation.journal | FEBS LETTERS | - |
dc.contributor.googleauthor | Heo, Yong-Seok | - |
dc.contributor.googleauthor | Jeon, Young Ho | - |
dc.contributor.googleauthor | Hong, Hyo Jeong | - |
dc.contributor.googleauthor | Wei, Chun Hua | - |
dc.contributor.googleauthor | Jeon, Jeong Yi | - |
dc.contributor.googleauthor | Ryu, Seong Eon | - |
dc.contributor.googleauthor | Jeon, Young Ho | - |
dc.contributor.googleauthor | Kim, Seung Jun | - |
dc.contributor.googleauthor | Lee, Eung Suk | - |
dc.contributor.googleauthor | Kim, Kyung Hyun | - |
dc.contributor.googleauthor | 허용석 | - |
dc.contributor.googleauthor | 전영호 | - |
dc.contributor.googleauthor | 홍효정 | - |
dc.contributor.googleauthor | 위춘화 | - |
dc.contributor.googleauthor | 전정이 | - |
dc.contributor.googleauthor | 류성언 | - |
dc.contributor.googleauthor | 전영호 | - |
dc.contributor.googleauthor | 김승준 | - |
dc.contributor.googleauthor | 이은석 | - |
dc.contributor.googleauthor | 김경현 | - |
dc.relation.code | 2011203177 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | ryuse | - |
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