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dc.contributor.author최한곤-
dc.date.accessioned2018-02-13T04:30:12Z-
dc.date.available2018-02-13T04:30:13Z-
dc.date.issued2015-07-
dc.identifier.citationINTERNATIONAL JOURNAL OF PHARMACEUTICS, v. 490, No. 1-2, Page. 240-247en_US
dc.identifier.issn0378-5173-
dc.identifier.issn1873-3476-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S037851731500486X?via%3Dihub-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/37054-
dc.description.abstractTo develop a novel sodium alginate based Centella asiatica (CA)-loaded hydrocolloid wound dressing (HCD) providing excellent mechanical properties and improved wound healing, numerous CA-loaded HCDs were prepared with various ingredients using the hot melting method. The effect of sodium alginate, styrene-isoprene-styrene copolymer (SIS) and petroleum hydrocarbon resin (PHR) on the mechanical properties of CA-loaded HCDs was investigated. The effect of disintegrants on swelling and drug release was assessed. Moreover, the in vivo wound healing potentials of the selected CA-loaded HCD in various wound models such as abrasion, excision and infection were evaluated in comparison with the commercial product. Polyisobutylene and SIS hardly affected the mechanical properties, but PHR improved the tensile strength and elongation at break. Disintegrants such as croscarmellose sodium, sodium starch glycolate and crospovidone improved the swelling ratio of the CA-loaded HCD. Furthermore, the CA-loaded HCD without croscarmellose sodium poorly released the drug, but that with 2% croscarmellose sodium showed about 27% drug release in 24 h. In particular, the CA-loaded HCD composed of CA/polyisobutylene/SIS/PHR/liquid paraffin/sodium alginate/croscarmellose sodium at the weight ratio of 1/8/25/25/12/27/2 furnished excellent mechanical properties and drug release. As compared with the commercial product, it offered improved healing effects in excision, infection and abrasion type wounds in rats. Thus, this novel CA-loaded HCD could be a potential candidate for the treatment of various wounds. (C) 2015 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipThis work was supported by the National Research Foundation of South Korea (NRF) grant funded by the South Korea government (MEST) (No. 2012R1A2A2A01045658).en_US
dc.language.isoen_USen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.subjectCentella asiatica-loaded wound dressingen_US
dc.subjectSodium alginateen_US
dc.subjectCroscarmellose sodiumen_US
dc.subjectWound healingen_US
dc.subjectTensile strengthen_US
dc.subjectElongation at breaken_US
dc.subjectSwelling ratioen_US
dc.subjectSODIUM ALGINATEen_US
dc.subjectPOLYVINYL-ALCOHOLen_US
dc.subjectCHITOSANen_US
dc.subjectSUPERDISINTEGRANTSen_US
dc.subjectDISINTEGRANTSen_US
dc.subjectFIBROBLASTSen_US
dc.subjectDISSOLUTIONen_US
dc.subjectCOMPOSITEen_US
dc.subjectSYSTEMen_US
dc.subjectDRUGSen_US
dc.titleMechanical properties and in vivo healing evaluation of a novel Centella asiatica-loaded hydrocolloid wound dressingen_US
dc.typeArticleen_US
dc.relation.no1-2-
dc.relation.volume490-
dc.identifier.doi10.1016/j.ijpharm.2015.05.058-
dc.relation.page240-247-
dc.relation.journalINTERNATIONAL JOURNAL OF PHARMACEUTICS-
dc.contributor.googleauthorJin, Sung Giu-
dc.contributor.googleauthorKim, Kyung Soo-
dc.contributor.googleauthorYousaf, Abid Mehmood-
dc.contributor.googleauthorKim, Dong Wuk-
dc.contributor.googleauthorJang, Sun Woo-
dc.contributor.googleauthorSon, Mi-Won-
dc.contributor.googleauthorKim, Young Hun-
dc.contributor.googleauthorYong, Chul Soon-
dc.contributor.googleauthorKim, Jong Oh-
dc.contributor.googleauthorChoi, Han Gon-
dc.relation.code2015002419-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidhangon-
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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