Anti-cancer effects of docetaxel loaded thermo-reversible hydrogels in a tumor xenograft mice model
- Title
- Anti-cancer effects of docetaxel loaded thermo-reversible hydrogels in a tumor xenograft mice model
- Author
- 김용희
- Keywords
- Docetaxel; Anti-cancer; Thermo-reversible hydrogel; Biocompatible natural polymer
- Issue Date
- 2011-11
- Publisher
- Elsevier, Inc.
- Citation
- Journal of Controlled Release. Nov 01, 2011, P44-45
- Abstract
- ABSTRACT SUMMARY: Thermo-reversible hydrogels consisting of low molecular weight methycellulose (LMwMC), pluronic F127 polymer and ammonium sulfate (AS) were optimized for controlled release of the hydrophobic drug, docetaxel (DTX). DTX loaded themo-reversible hydrogels showed sustained release of DTX over 25 days with no significant burst release. Compared to free DTX, DTX loaded hydrogel significantly reduced tumor growth and increased the survival rate of B16-F10 melanoma cancer cell bearing mice. Injectable and thermo-reversible hydrogels can be widely applied as efficient carriers for hydrophobic anti-cancer drugs.
- URI
- http://www.sciencedirect.com/science/article/pii/S0168365911007267?via%3Dihub
- ISSN
- 0168-3659; 1873-4995
- DOI
- 10.1016/j.jconrel.2011.08.112
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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