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Suicidal gene therapy against tumor using reducible poly (oligo-d-arginine)

Title
Suicidal gene therapy against tumor using reducible poly (oligo-d-arginine)
Author
김용희
Keywords
Suicide gene therapy; HSV-TK; Ganciclovir; Non-viral gene carrier
Issue Date
2011-11
Publisher
Elsevier, Inc.
Citation
Journal of Controlled Release. Nov 01, 2011, P148-149
Abstract
SUMMARY: Reducible poly(oligo-D-arginine) (rPOA) is a promising non-viral gene delivery carrier, providing lower cytotoxicity and higher gene expression efficiency compare to PEI. rPOA showed a higher level of HSV-TK gene expression in comparison with PEI in brain tumor cells and subsequently induced high cytotoxicity on tumor cells, in the presence of ganciclovir (GCV).
URI
http://www.sciencedirect.com/science/article/pii/S0168365911006687?via%3Dihub
ISSN
0168-3659; 1873-4995
DOI
10.1016/j.jconrel.2011.08.054
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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