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Optical Imaging and Gene Therapy with Neuroblastoma-Targeting Polymeric Nanoparticles for Potential Theranostic Applications

Title
Optical Imaging and Gene Therapy with Neuroblastoma-Targeting Polymeric Nanoparticles for Potential Theranostic Applications
Author
이근용
Keywords
NICOTINIC ACETYLCHOLINE-RECEPTORS; DRUG-DELIVERY; CANCER-THERAPY; MULTIFUNCTIONAL NANOPARTICLES; RABIES VIRUS; PLGA NANOPARTICLES; EPITHELIAL-CELLS; NERVOUS-SYSTEM; C-MYC; GLYCOPROTEIN
Issue Date
2016-03
Publisher
WILEY-V C H VERLAG GMBH
Citation
SMALL, v. 12, NO 9, Page. 1201-1211
Abstract
Recently, targeted delivery systems based on functionalized polymeric nanoparticles have attracted a great deal of attention in cancer diagnosis and therapy. Specifically, as neuroblastoma occurs in infancy and childhood, targeted delivery may be critical to reduce the side effects that can occur with conventional approaches, as well as to achieve precise diagnosis and efficient therapy. Thus, biocompatible poly(D,L-lactide-co-glycolide) (PLG) nanoparticles containing an imaging probe and therapeutic gene are prepared, followed by modification with rabies virus glycoprotein (RVG) peptide for neuroblastoma-targeting delivery. RVG peptide is a well-known neuronal targeting ligand and is chemically conjugated to PLG nanoparticles without changing their size or shape. RVG-modified nanoparticles are effective in specifically targeting neuroblastoma both in vitro and in vivo. RVG-modified nanoparticles loaded with a fluorescent probe are useful to detect the tumor site in a neuroblastoma-bearing mouse model, and those encapsulating a therapeutic gene cocktail (siMyc, siBcl-2, and siVEGF) significantly suppressed tumor growth in the mouse model. This approach to designing and tailoring of polymeric nanoparticles for targeted delivery may be useful in the development of multimodality systems for theranostic approaches.
URI
http://onlinelibrary.wiley.com/doi/10.1002/smll.201501913/abstract;jsessionid=312A4DFA1FD3EE01C9F3EF3BC6986DB2.f01t02http://hdl.handle.net/20.500.11754/37003
ISSN
1613-6810; 1613-6829
DOI
10.1002/smll.201501913
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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