91 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author이주연-
dc.date.accessioned2018-02-13T02:13:12Z-
dc.date.available2018-02-13T02:13:12Z-
dc.date.issued2015-07-
dc.identifier.citationPLOS ONE, v. 10, No. 7, Article ID e0132916en_US
dc.identifier.issn1932-6203-
dc.identifier.urihttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132916-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/36995-
dc.description.abstractPurpose To evaluate the clinical manifestations and causative drugs associated with adverse drug reactions (ADRs) spontaneously reported by community pharmacists and to compare the ADRs by age. Methods ADRs reported to the Regional Pharmacovigilance Center of the Korean Pharmaceutical Association by community pharmacists from January 2013 to June 2014 were included. Causality was assessed using the WHO-Uppsala Monitoring Centre system. The patient population was classified into three age groups. We analyzed 31,398 (74.9%) ADRs from 9,705 patients, identified as having a causal relationship, from a total pool of 41,930 ADRs from 9,873 patients. Median patient age was 58.0 years; 66.9% were female. Results Gastrointestinal system (34.4%), nervous system (14.4%), and psychiatric (12.1%) disorders were the most frequent symptoms. Prevalent causative drugs were those for acid-related disorders (11.4%), anti-inflammatory products (10.5%), analgesics (7.2%), and anti-bacterials (7.1%). Comparisons by age revealed diarrhea and antibacterials to be most commonly associated with ADRs in children (p < 0.001), whereas dizziness was prevalent in the elderly (p < 0.001). Anaphylactic reaction was the most frequent serious event (19.7%), mainly associated with cephalosporins and non-steroidal anti-inflammatory drugs. Among 612 ADRs caused by nonprescription drugs, the leading symptoms and causative drugs were skin disorders (29.6%) and non-steroidal anti-inflammatory drugs (16.2%), respectively. Conclusions According to the community pharmacist reports, the leading clinical manifestations and causative drugs associated with ADRs in outpatients differed among age groups.en_US
dc.description.sponsorshipThis research was supported by a grant from Ministry of Food and Drug Safety (http://www.mfds.go.kr/index.do) to operation of the regional pharmacovigilance center in 2014 (20140114-000012). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.language.isoen_USen_US
dc.publisherPUBLIC LIBRARY SCIENCEen_US
dc.subjectAMBULATORY-CAREen_US
dc.subjectGENDER-DIFFERENCESen_US
dc.subjectEVENTSen_US
dc.subjectPREVALENCEen_US
dc.subjectDIZZINESSen_US
dc.subjectMEDICINEen_US
dc.titlePatterns of Adverse Drug Reactions in Different Age Groups: Analysis of Spontaneous Reports by Community Pharmacistsen_US
dc.typeArticleen_US
dc.relation.no7-
dc.relation.volume10-
dc.identifier.doi10.1371/journal.pone.0132916-
dc.relation.page1-11-
dc.relation.journalPLOS ONE-
dc.contributor.googleauthorYu, YM-
dc.contributor.googleauthorShin, WG-
dc.contributor.googleauthorLee, JY-
dc.contributor.googleauthorChoi, SA-
dc.contributor.googleauthorJo, YH-
dc.contributor.googleauthorYoun, SJ-
dc.contributor.googleauthorLee, MS-
dc.contributor.googleauthorChoi, KH-
dc.relation.code2015008685-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidjypharm-
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE