Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이근용 | - |
dc.date.accessioned | 2018-02-13T02:09:16Z | - |
dc.date.available | 2018-02-13T02:09:16Z | - |
dc.date.issued | 2011-11 | - |
dc.identifier.citation | Journal of Controlled Release. Nov 2011, P165-166 | en_US |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.uri | www.sciencedirect.com/science/article/pii/S0168365911006791?via%3Dihub | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/36991 | - |
dc.description.abstract | SUMMARY: Small interfering RNA (siRNA) has been widely investigated as a potential therapeutic for treatment of various diseases. However, naked siRNA is rapidly degraded by nucleases, showing poor cellular uptake and low transfection efficiency. Chitosan-based nanoparticles have been extensively exploited as a gene delivery carrier due to low toxicity and positively charged amino groups of chitosan. In this study, we synthesized 9R-modified chitosan and used it to form stable nanoparticles in the presence of siRNA. Various physicochemical properties of the nanoparticles, including size, surface charge, and complex forming ability, were investigated. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS | en_US |
dc.subject | Chitosan | en_US |
dc.subject | Arginine | en_US |
dc.subject | siRNA | en_US |
dc.subject | Gene delivery | en_US |
dc.title | Oligoarginine-modified chitosan for siRNA delivery | en_US |
dc.type | Article | en_US |
dc.relation.volume | 152 | - |
dc.identifier.doi | 10.1016/j.jconrel.2011.08.065 | - |
dc.relation.page | 165-166 | - |
dc.relation.journal | JOURNAL OF CONTROLLED RELEASE | - |
dc.contributor.googleauthor | Park, Soyeon | - |
dc.contributor.googleauthor | Lee, Sang Kyung | - |
dc.contributor.googleauthor | Lee, Kuen Yong | - |
dc.contributor.googleauthor | 박소연 | - |
dc.contributor.googleauthor | 이상경 | - |
dc.contributor.googleauthor | 이근용 | - |
dc.relation.code | 2011204927 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | leeky | - |
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