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dc.contributor.author이근용-
dc.date.accessioned2018-02-13T02:09:16Z-
dc.date.available2018-02-13T02:09:16Z-
dc.date.issued2011-11-
dc.identifier.citationJournal of Controlled Release. Nov 2011, P165-166en_US
dc.identifier.issn0168-3659-
dc.identifier.uriwww.sciencedirect.com/science/article/pii/S0168365911006791?via%3Dihub-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/36991-
dc.description.abstractSUMMARY: Small interfering RNA (siRNA) has been widely investigated as a potential therapeutic for treatment of various diseases. However, naked siRNA is rapidly degraded by nucleases, showing poor cellular uptake and low transfection efficiency. Chitosan-based nanoparticles have been extensively exploited as a gene delivery carrier due to low toxicity and positively charged amino groups of chitosan. In this study, we synthesized 9R-modified chitosan and used it to form stable nanoparticles in the presence of siRNA. Various physicochemical properties of the nanoparticles, including size, surface charge, and complex forming ability, were investigated.en_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSen_US
dc.subjectChitosanen_US
dc.subjectArginineen_US
dc.subjectsiRNAen_US
dc.subjectGene deliveryen_US
dc.titleOligoarginine-modified chitosan for siRNA deliveryen_US
dc.typeArticleen_US
dc.relation.volume152-
dc.identifier.doi10.1016/j.jconrel.2011.08.065-
dc.relation.page165-166-
dc.relation.journalJOURNAL OF CONTROLLED RELEASE-
dc.contributor.googleauthorPark, Soyeon-
dc.contributor.googleauthorLee, Sang Kyung-
dc.contributor.googleauthorLee, Kuen Yong-
dc.contributor.googleauthor박소연-
dc.contributor.googleauthor이상경-
dc.contributor.googleauthor이근용-
dc.relation.code2011204927-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDEPARTMENT OF BIOENGINEERING-
dc.identifier.pidleeky-
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COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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