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Oligoarginine-modified chitosan for siRNA delivery

Title
Oligoarginine-modified chitosan for siRNA delivery
Author
이근용
Keywords
Chitosan; Arginine; siRNA; Gene delivery
Issue Date
2011-11
Publisher
ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
Citation
Journal of Controlled Release. Nov 2011, P165-166
Abstract
SUMMARY: Small interfering RNA (siRNA) has been widely investigated as a potential therapeutic for treatment of various diseases. However, naked siRNA is rapidly degraded by nucleases, showing poor cellular uptake and low transfection efficiency. Chitosan-based nanoparticles have been extensively exploited as a gene delivery carrier due to low toxicity and positively charged amino groups of chitosan. In this study, we synthesized 9R-modified chitosan and used it to form stable nanoparticles in the presence of siRNA. Various physicochemical properties of the nanoparticles, including size, surface charge, and complex forming ability, were investigated.
URI
www.sciencedirect.com/science/article/pii/S0168365911006791?via%3Dihubhttp://hdl.handle.net/20.500.11754/36991
ISSN
0168-3659
DOI
10.1016/j.jconrel.2011.08.065
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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