Oligoarginine-modified chitosan for siRNA delivery
- Title
- Oligoarginine-modified chitosan for siRNA delivery
- Author
- 이근용
- Keywords
- Chitosan; Arginine; siRNA; Gene delivery
- Issue Date
- 2011-11
- Publisher
- ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
- Citation
- Journal of Controlled Release. Nov 2011, P165-166
- Abstract
- SUMMARY: Small interfering RNA (siRNA) has been widely investigated as a potential therapeutic for treatment of various diseases. However, naked siRNA is rapidly degraded by nucleases, showing poor cellular uptake and low transfection efficiency. Chitosan-based nanoparticles have been extensively exploited as a gene delivery carrier due to low toxicity and positively charged amino groups of chitosan. In this study, we synthesized 9R-modified chitosan and used it to form stable nanoparticles in the presence of siRNA. Various physicochemical properties of the nanoparticles, including size, surface charge, and complex forming ability, were investigated.
- URI
- www.sciencedirect.com/science/article/pii/S0168365911006791?via%3Dihubhttp://hdl.handle.net/20.500.11754/36991
- ISSN
- 0168-3659
- DOI
- 10.1016/j.jconrel.2011.08.065
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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