Changes in Vascular Endothelial Growth Factor (VEGF) Induced by the Morris Water Maze Task
- Title
- Changes in Vascular Endothelial Growth Factor (VEGF) Induced by the Morris Water Maze Task
- Author
- 손현
- Keywords
- learning; morris water maze; VEGF
- Issue Date
- 2012-01
- Publisher
- OXFORD UNIV PRESS, GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
- Citation
- INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 권: 15, 페이지: 165-165
- Abstract
- The present study was undertaken to evaluate the effects on hippocampal vascular endothelial growth factor (VEGF) levels in rats when they experience hippocampal-dependent spatial learning via the Morris water maze (MWM) task. Rats underwent one of two different versions of the MWM: weak or intensive. After one day of intensive training, a highly sensitive enzyme-linked immunosorbent assay (ELISA) was used to measure VEGF protein levels in the hippocampus, cortex, and serum, and higher levels were found in the trained group compared to a naive control group. VEGF levels also increased in rats that swam only for durations equal to the intensive training periods. In contrast, rats trained under the weaker MWM paradigm for five days showed a decrease in hippocampal VEGF protein level. Mimicking increases in neuronal VEGF in the hippocampus by direct infusion of VEGF into CA1 resulted in up-regulation of the phosphorylation of the cAMP response element-binding (CREB) protein and the Ca/calmodulin-dependent protein kinases II (CaMKII). These results suggest that VEGF may be a physiological parameter involved in learning procedures that include physical activity. [ABSTRACT FROM AUTHOR]
- URI
- http://search.proquest.com/docview/929147986?accountid=11283http://hdl.handle.net/20.500.11754/36915
- ISSN
- 1016-8478
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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