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Adenovirus-relaxin gene therapy for keloids: implication for reversing pathological fibrosis

Title
Adenovirus-relaxin gene therapy for keloids: implication for reversing pathological fibrosis
Author
윤채옥
Keywords
FIBROBLASTS; EFFICACY; HORMONE
Issue Date
2011-09
Publisher
WILEY-BLACKWELL, COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
Citation
British Journal of Dermatology, Vol.165, No.3 [2011], p673-677
Abstract
Background Keloids or hypertrophic scars are pathological proliferations of the dermal skin layer resulting from excessive collagen deposition. Because the hormone relaxin (RLX) inhibits collagen synthesis and expression in stimulated fibroblasts, an adenovirus expressing RLX (dE1-RGD/lacZ/RLX) was generated.Objectives To investigate the effect of RLX-expressing adenovirus on expression of various extracellular matrix (ECM) components in primary keloid spheroids.Methods The expression levels of type I and III collagen, fibronectin and elastin were investigated by immunohistochemistry in primary keloid spheroids transduced with the RLX-expressing adenovirus.Results Immunohistochemical analysis showed that expression of major ECM components (e. g. type I and III collagen, elastin and fibronectin) was markedly reduced in primary keloid spheroids transduced with dE1-RGD/lacZ/RLX.Conclusions These results suggest that the antifibrotic effect of RLX-expressing adenovirus may have therapeutic effects on keloids by reversing pathological fibrosis and preventing keloid recurrence after surgical excision.
URI
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2133.2011.10439.x/abstracthttp://hdl.handle.net/20.500.11754/36767
ISSN
0007-0963
DOI
10.1111/j.1365-2133.2011.10439.x
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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