Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정승준 | - |
dc.date.accessioned | 2018-02-12T02:49:40Z | - |
dc.date.available | 2018-02-12T02:49:40Z | - |
dc.date.issued | 2011-06 | - |
dc.identifier.citation | International Journal of Oral Biology, 2011, 36(2), P.83-89 | en_US |
dc.identifier.issn | 2287-6618 | - |
dc.identifier.issn | 1226-7155 | - |
dc.identifier.uri | https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001559583 | - |
dc.description.abstract | Substantia gelatinosa (SG) neurons receive synaptic inputs from primary afferent Aδ- and C-fibers, where nociceptive information is integrated and modulated by numerous neurotransmitters or neuromodulators. A number of studies were dedicated to the molecular mechanism underlying the modulation of excitability or synaptic plasticity in SG neurons and revealed that second messengers, such as cAMP and cGMP, play an important role. Recently, cAMP and cGMP were shown to downregulate each other in heart muscle cells. However, involvement of the crosstalk between cAMP and cGMP in neurons is yet to be addressed. Therefore, we investigated whether interaction between cAMP and cGMP modulates synaptic plasticity in SG neurons using slice patchclamp recording from rats. Synaptic activity was measured by excitatory post-synaptic currents (EPSCs) elicited by stimulation onto dorsal root entry zone. Application of 1 mM of 8- bromoadenosine 3,5-cyclic monophosphate (8-Br-cAMP) or 8-bromoguanosine 3,5-cyclic monophosphate (8-Br-cGMP) for 15 minutes increased EPSCs, which were maintained for 30 minutes. However, simultaneous application of 8-BrcAMP and 8-Br-cGMP failed to increase EPSCs, which suggested antagonistic cross-talk between two second messengers. Application of 3-isobutyl-1-methylxanthine (IBMX) that prevents degradation of cAMP and cGMP by blocking phosphodiesterase (PDE) increased EPSCs. Co-application of cAMP/cGMP along with IBMX induced additional increase in EPSCs. These results suggest that second messengers, cAMP and cGMP, might contribute to development of chronic pain through the mutual regulation of the signal transduction. | en_US |
dc.description.sponsorship | 이 논문은 2006년 서울대학교 발전기금의 지원과 2008년 정부(교육과학기술부) 한국연구재단의 기초의과학연구센터육성사업(Medical science and engineering Research Center: MRC)의 지원(Grant 2010-0029510)을 받아 수행된 연구임 | en_US |
dc.language.iso | ko_KR | en_US |
dc.publisher | Korean ACAD of Oral Biology | en_US |
dc.subject | substantia gelatinosa | en_US |
dc.subject | spinal cord slice | en_US |
dc.subject | patch clamp | en_US |
dc.subject | cAMP | en_US |
dc.subject | cGMP | en_US |
dc.subject | 의약학 | en_US |
dc.subject | 치의학 | en_US |
dc.title | Involvement of Crosstalk Between cAMP and cGMP in Synaptic Plasticity in the Substantia Gelatinosa Neurons. | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 36 | - |
dc.relation.page | 83-89 | - |
dc.relation.journal | International Journal of Oral Biology | - |
dc.contributor.googleauthor | Oh, Seog Bae | - |
dc.contributor.googleauthor | Kim, Tae-Hyung | - |
dc.contributor.googleauthor | Chung, Gehoon | - |
dc.contributor.googleauthor | Park, Seok-Beom | - |
dc.contributor.googleauthor | Chey, Won-Young | - |
dc.contributor.googleauthor | Jung, Sung Jun | - |
dc.contributor.googleauthor | Kim, Joong Soo | - |
dc.relation.code | 2012218957 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | eurijj | - |
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