Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kevin Kyungsik Choe | - |
dc.date.accessioned | 2018-02-09T06:42:27Z | - |
dc.date.available | 2018-02-09T06:42:27Z | - |
dc.date.issued | 2015-06 | - |
dc.identifier.citation | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, V. 2015, Article ID 631329 | en_US |
dc.identifier.issn | 1741-427X | - |
dc.identifier.issn | 1741-4288 | - |
dc.identifier.uri | https://www.hindawi.com/journals/ecam/2015/631329/abs/ | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/36380 | - |
dc.description.abstract | Eurycoma longifolia (Simaroubaceae) is a popular folk medicine that has traditionally been used in Southeast Asia as an antimalarial, aphrodisiac, antidiabetic, and antimicrobial and in antipyretic remedies. This study evaluates the effects of Eurycoma longifolia extract on cytochrome P450 (CYP) enzyme-mediated drug metabolism to predict the potential for herb-drug interactions. Methanolic extract of E. longifolia root was tested at concentrations of 1, 3, 10, 30, 100, 300, and 1000 mu g/mL in human liver microsomes or individual recombinant CYP isozymes. The CYP inhibitory activity was measured using the cocktail probe assay based on liquid chromatography-tandem mass spectrometry. E. longifolia showed weak, concentration-dependent inhibition of CYP1A2, CYP2A6, and CYP2C19. The inhibitory effects on these CYP isozymes were further tested using individual recombinant CYP isozymes, showing IC50 values of 324.9, 797.1, and 562.9 mu g/mL, respectively. In conclusion, E. longifolia slightly inhibited the metabolic activities of CYP1A2, CYP2A6, and CYP2C19 but this issue requires careful attention in taking herbal medicines or dietary supplements containing E. longifolia extracts. | en_US |
dc.description.sponsorship | This work was supported by the research fund of Hanyang University (HY-2013-G). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | HINDAWI PUBLISHING CORPORATION | en_US |
dc.subject | HUMAN CYTOCHROME-P450 ENZYMES | en_US |
dc.subject | BETA-CARBOLINE ALKALOIDS | en_US |
dc.subject | ROOTS | en_US |
dc.subject | CONSTITUENTS | en_US |
dc.subject | QUASSINOIDS | en_US |
dc.subject | INHIBITION | en_US |
dc.title | In Vitro Evaluation of the Effects of Eurycoma longifolia Extract on CYP-Mediated Drug Metabolism | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1155/2015/631329 | - |
dc.relation.page | 631329-631329 | - |
dc.relation.journal | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.contributor.googleauthor | Han, Young Min | - |
dc.contributor.googleauthor | Kim, In Sook | - |
dc.contributor.googleauthor | Rehman, Shaheed Ur | - |
dc.contributor.googleauthor | Choe, Kevin Kyungsik | - |
dc.contributor.googleauthor | Yoo, Hye Hyun | - |
dc.relation.code | 2015012377 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | kkchoe | - |
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