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dc.contributor.author문효방-
dc.date.accessioned2018-02-08T07:30:28Z-
dc.date.available2018-02-08T07:30:28Z-
dc.date.issued2015-05-
dc.identifier.citationPLOS ONE, v. 10, No. 5en_US
dc.identifier.issn1932-6203-
dc.identifier.urihttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0125213-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/36300-
dc.description.abstract"Current knowledge on adverse endocrine disruption effects of persistent organic pollutants (POPs) among newborn infants is limited and often controversial. To investigate the associations between prenatal exposure to major POPs and thyroid hormone levels among newborn infants, both cord serum or maternal serum concentrations of polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and organochlorine pesticides (OCPs) were compared with five thyroid hormones in cord serum of newborn infants as well as TSH in bloodspot collected at 2 day after birth (n= 104). Since cord serum thyroid hormones could be affected by those of mothers, thyroid hormone concentrations of the matching mothers at delivery were adjusted. In cord serum, BDE-47, -99, and Sigma chlordane (CHD) showed significant positive associations with cord or bloodspot TSH. At the same time, p, p'-dichlorodiphenyldichloroethylene #p, p'-DDE# and hexachlorbenzene #HCB# showed negative associations with total T3 and total T4 in cord serum, respectively. Maternal exposure to beta-hexachlorhexane #beta-HCH#, SCHD, SDDT, or p, p'-DDE were also associated with neonatal thyroid hormones. Although the sample size is small and the thyroid hormone levels of the subjects were within the reference range, our observation supports thyroid disrupting potential of several POPs among newborn infants, at the levels occurring in the general population. Considering the importance of thyroid hormones during gestation and early life stages, health implication of thyroid hormone effects by low level POPs exposure deserves further follow up investigations."en_US
dc.description.sponsorshipThis work was supported by a grant (11162MFDS722) from the Ministry of Food and Drug Safety of Korea(http://rnd.mfds.go.kr) in 2011 and the National Research Foundation of Korea (Project 2012R1A2A2A01015236, http://www.nrf.re.kr/nrf_eng_cms). S. M. Kim is supported by BK 21 Plus program of National Research Foundation of Korea (https://bkplus.nrf.re.kr). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.language.isoen_USen_US
dc.publisherPUBLIC LIBRARY SCIENCEen_US
dc.subjectPOLYBROMINATED DIPHENYL ETHERSen_US
dc.subjectPOLYCHLORINATED-BIPHENYLS PCBSen_US
dc.subjectENDOCRINE-DISRUPTING CHEMICALSen_US
dc.subjectBROMINATED FLAME RETARDANTSen_US
dc.subjectTIME-COURSE VARIATIONen_US
dc.subjectSPRAGUE-DAWLEY RATSen_US
dc.subjectHUMAN BREAST-MILKen_US
dc.subjectSTIMULATING HORMONEen_US
dc.subjectORGANOCHLORINE COMPOUNDSen_US
dc.subjectPRENATAL EXPOSUREen_US
dc.titleAssociation between Several Persistent Organic Pollutants and Thyroid Hormone Levels in Cord Blood Serum and Bloodspot of the Newborn Infants of Koreaen_US
dc.typeArticleen_US
dc.relation.volume10-
dc.identifier.doi10.1371/journal.pone.0125213-
dc.relation.page1-10-
dc.relation.journalPLOS ONE-
dc.contributor.googleauthorKim, SM-
dc.contributor.googleauthorPark, JI-
dc.contributor.googleauthorKim, HJ-
dc.contributor.googleauthorLee, JJ-
dc.contributor.googleauthorChoi, GY-
dc.contributor.googleauthorChoi, SR-
dc.contributor.googleauthorKim, SJ-
dc.contributor.googleauthorKim, SY-
dc.contributor.googleauthorMoon, HB-
dc.contributor.googleauthorKim, SK-
dc.contributor.googleauthorChoi, KH-
dc.relation.code2015008685-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E]-
dc.sector.departmentMARINE SCIENCE AND CONVERGENCE ENGINEERING-
dc.identifier.pidhbmoon-


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