Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김정목 | - |
dc.date.accessioned | 2018-02-08T01:35:38Z | - |
dc.date.available | 2018-02-08T01:35:38Z | - |
dc.date.issued | 2011-08 | - |
dc.identifier.citation | Journal of Immunology Vol.187 No.4 [2011],1931-1941P | en_US |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | http://www.jimmunol.org/content/187/4/1931 | - |
dc.description.abstract | Enterotoxigenic Bacteroides fragilis (ETBF) produces a similar to 20-kDa heat-labile enterotoxin (BFT) that plays an essential role in mucosal inflammation. Although a variety of inflammatory cells is found at ETBF-infected sites, little is known about leukocyte adhesion in response to BFT stimulation. We investigated whether BFT affected the expression of ICAM-1 and monocytic adhesion to endothelial cells (ECs). Stimulation of HUVECs and rat aortic ECs with BFT resulted in the induction of ICAM-1 expression. Upregulation of ICAM-1 was dependent on the activation of I kappa B kinase (IKK) and NF-kappa B signaling. In contrast, suppression of AP-1 did not affect ICAM-1 expression in BFT-stimulated cells. Suppression of NF-kappa B activity in HUVECs significantly reduced monocytic adhesion, indicating that ICAM-1 expression is indispensable for BFT-induced adhesion of monocytes to the endothelium. Inhibition of JNK resulted in a significant attenuation of BFT-induced ICAM-1 expression in ECs. Moreover, inhibition of aldose reductase significantly reduced JNK-dependent IKK/NF-kappa B activation, ICAM-1 expression, and adhesion of monocytes to HUVECs. These results suggest that a signaling pathway involving aldose reductase, JNK, IKK, and NF-kappa B is required for ICAM-1 induction in ECs exposed to BFT, and may be involved in the leukocyte-adhesion cascade following infection with ETBF. The Journal of Immunology, 2011, 187: 1931-1941. | en_US |
dc.language.iso | en | en_US |
dc.publisher | AMER ASSOC IMMUNOLOGISTS, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA | en_US |
dc.subject | INTESTINAL EPITHELIAL-CELLS | en_US |
dc.subject | CLOSTRIDIUM-DIFFICILE TOXIN | en_US |
dc.subject | ACTIVATED PROTEIN-KINASE | en_US |
dc.subject | TRANSCRIPTION FACTORS | en_US |
dc.subject | LEUKOCYTE ADHESION | en_US |
dc.subject | VCAM-1 EXPRESSION | en_US |
dc.subject | SIGNALING PATHWAY | en_US |
dc.subject | ICAM-1 EXPRESSION | en_US |
dc.subject | INDUCED ENTERITIS | en_US |
dc.subject | GENE-EXPRESSION | en_US |
dc.title | Bacteroides fragilis Enterotoxin Upregulates Intercellular Adhesion Molecule-1 in Endothelial Cells via an Aldose Reductase-, MAPK-, and NF-kappa B-Dependent Pathway, Leading to Monocyte Adhesion to Endothelial Cells | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 187 | - |
dc.identifier.doi | 10.4049/jimmunol.1101226 | - |
dc.relation.page | 1931-1941 | - |
dc.relation.journal | JOURNAL OF IMMUNOLOGY | - |
dc.contributor.googleauthor | Roh, Hyun Cheol | - |
dc.contributor.googleauthor | Yoo, Do Young | - |
dc.contributor.googleauthor | Ko, Su Hyuk | - |
dc.contributor.googleauthor | Kim, Young-Jeon | - |
dc.contributor.googleauthor | Kim, Jung Mogg | - |
dc.relation.code | 2011205241 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jungmogg | - |
dc.identifier.orcid | http://orcid.org/0000-0002-6506-7519 | - |
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