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Intravascular optical imaging of high-risk plaques in vivo by targeting macrophage mannose receptors

Title
Intravascular optical imaging of high-risk plaques in vivo by targeting macrophage mannose receptors
Author
유홍기
Keywords
HUMAN ATHEROSCLEROTIC PLAQUES; MATRIX METALLOPROTEINASES; CORONARY-DISEASE; NANOPARTICLES; EXPRESSION; CHITOSAN; CELLS; BIODISTRIBUTION; PATHOGENESIS; INFLAMMATION
Issue Date
2016-03
Publisher
NATURE PUBLISHING GROUP
Citation
SCIENTIFIC REPORTS, v. 6, NO 22608, Page. 1-11
Abstract
Macrophages mediate atheroma expansion and disruption, and denote high-risk arterial plaques. Therefore, they are substantially gaining importance as a diagnostic imaging target for the detection of rupture-prone plaques. Here, we developed an injectable near-infrared fluorescence (NIRF) probe by chemically conjugating thiolated glycol chitosan with cholesteryl chloroformate, NIRF dye (cyanine 5.5 or 7), and maleimide-polyethylene glycol-mannose as mannose receptor binding ligands to specifically target a subset of macrophages abundant in high-risk plaques. This probe showed high affinity to mannose receptors, low toxicity, and allowed the direct visualization of plaque macrophages in murine carotid atheroma. After the scale-up of the MMR-NIRF probe, the administration of the probe facilitated in vivo intravascular imaging of plaque inflammation in coronary-sized vessels of atheromatous rabbits using a custom-built dual-modal optical coherence tomography (OCT)-NIRF catheter-based imaging system. This novel imaging approach represents a potential imaging strategy enabling the identification of high-risk plaques in vivo and holds promise for future clinical implications.
URI
https://www.nature.com/articles/srep22608http://hdl.handle.net/20.500.11754/36039
ISSN
2045-2322
DOI
10.1038/srep22608
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
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