Informed consent is one of the main demands in medical practices. Because xenotransplantation is a type of medical practices, it also needs informed consent of patient. Informed consent is valid, if the patient is competent, has sufficient understanding about the relevant information, and consents freely; competency, understanding, and voluntariness. However, the patient who would be a subject of xenotransplantation may not have another choice other than receiving xenografts because if he may not he would die. So, voluntariness of consent in xenotransplantation should be examined carefully. Also, sufficient understanding of the relevant information may not be satisfied. Patient may not sufficiently understand the relevant information because there is no or enough relevant information about xenotransplantation. Another issue which is related with xenotransplantation is informed consent of patient’s relatives. They may be kept a close watch by the medical professionals during their life because of the patient who lives with them. If they do not give informed consent they may not live with patient any more. So, voluntariness of informed consent of patient’s relatives should be examined carefully. Also, sufficient understanding of relevant information by patient’s relatives should be considered. If we can not meet the elements of informed consent in xenotransplantation, we should consider the modification of the elements of informed consent or other ethical principles which would supplement informed consent. Beneficence would be an ethical principle which can make up for it’s fault. Informed consent is not the only element which should be considered in medical practices. Also, we should consider medical professionals’ autonomy as well as patients’ one.