Highly sensitive SERS-based immunoassay of aflatoxin B1 using silica-encapsulated hollow gold nanoparticles
- Title
- Highly sensitive SERS-based immunoassay of aflatoxin B1 using silica-encapsulated hollow gold nanoparticles
- Author
- 이찬길
- Keywords
- Aflatoxin B1; Mycotoxin; Surface-enhanced Raman scattering; Silica-encapsulation; Magnetic bead; ENHANCED RAMAN-SCATTERING; RAPID DETECTION; MYCOTOXINS; CONTAMINATION; NANOSPHERES; NANOPROBES; ANTIGEN; MARKERS; HEALTH; SENSOR
- Issue Date
- 2015-03
- Publisher
- ELSEVIER SCIENCE BV
- Citation
- JOURNAL OF HAZARDOUS MATERIALS, v. 285, Page. 11-17
- Abstract
- "Aflatoxin B1 (AFB1) is a well-known carcinogenic contaminant in foods. It is classified as an extremely hazardous compound because of its potential toxicity to the human nervous system. AFB1 has also been extensively used as a biochemical marker to evaluate the degree of food spoilage. In this study, a novel surface-enhanced Raman scattering (SERS)-based immunoassay platform using silica-encapsulated hollow gold nanoparticles (SEHGNs) and magnetic beads was developed for highly sensitive detection of AFB1.SEHGNs were used as highly stable SERS-encoding nano tags, and magnetic beads were used as supporting substrates for the high-density loading of immunocomplexes. Quantitative analysis of AFB1 was performed by monitoring the intensity change of the characteristic peaks of Raman reporter molecules. The limit of detection (LOD) of AFB1, determined by this SERS-based immunoassay, was determined to be 0.1 ng/mL. This method has some advantages over other analytical methods with respect to rapid analysis (less than 30 min), good selectivity, and reproducibility. The proposed method is expected to be a new analytical tool for the trace analysis of various mycotoxins. (C) 2014 Elsevier B.V. All rights reserved."
- URI
- https://www.sciencedirect.com/science/article/pii/S0304389414009182http://hdl.handle.net/20.500.11754/35589
- ISSN
- 0304-3894; 1873-3336
- DOI
- 10.1016/j.jhazmat.2014.11.018
- Appears in Collections:
- COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > ELECTRICAL ENGINEERING(전자공학부) > Articles
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML