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dc.contributor.author이영식-
dc.date.accessioned2018-02-05T07:33:36Z-
dc.date.available2018-02-05T07:33:36Z-
dc.date.issued2015-01-
dc.identifier.citationJOURNAL OF MOLECULAR NEUROSCIENCE, v. 55, No. 1, Page. 109-125en_US
dc.identifier.issn0895-8696-
dc.identifier.issn1559-1166-
dc.identifier.urihttps://link.springer.com/article/10.1007/s12031-014-0382-8-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/35433-
dc.description.abstract"Many genes are associated with the differentiation of neural stem cells (NSCs) into astrocytes, the most abundant and functionally diverse population of glial cells in the central nervous system, particularly in the brain. In the present study, we differentiated NSCs from the forebrain of embryonic day 14.5 mouse embryos into astrocytes over 1 and 7 days. We identified transcriptomes of NSCs and astrocytes using RNA sequencing and analyzed enriched gene networks, signal pathways, and ontology. To identify important regulators of differentiation, we performed gene clustering according to expression patterns and promoter CG types. Our data show that genes related to system development, including Fbln2, Bcan, Ncam1, Itih3, Tnr, and Vcan, regulate NSC differentiation through WNT/beta-catenin and epithelial to mesenchymal transition pathways. We identified many CG-rich promoter genes related to basic cellular maintenance such as transcription, translation, and structural components and CG-poor promoter genes that are highly associated with cell-type-specific functions or play important roles during development. Our study provides a foundation for further research on NSC differentiation and the future application of stem cells."en_US
dc.description.sponsorshipThis work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2011-0030049).en_US
dc.language.isoen_USen_US
dc.publisherHUMANA PRESS INCen_US
dc.subjectNeural stem cellsen_US
dc.subjectAstrocytesen_US
dc.subjectCell differentiationen_US
dc.subjectTGF betaen_US
dc.subjectWNTsen_US
dc.subjectIN-VIVOen_US
dc.subjectRNA-SEQen_US
dc.subjectEXPRESSIONen_US
dc.subjectSPECIFICATIONen_US
dc.subjectIDENTIFICATIONen_US
dc.subjectOLIGODENDROCYTESen_US
dc.subjectPLURIPOTENTen_US
dc.subjectINSIGHTSen_US
dc.subjectCULTURESen_US
dc.subjectDATABASEen_US
dc.titleGlobal Transcriptome Profiling of Genes that Are Differentially Regulated During Differentiation of Mouse Embryonic Neural Stem Cells into Astrocytesen_US
dc.typeArticleen_US
dc.relation.volume55-
dc.identifier.doi10.1007/s12031-014-0382-8-
dc.relation.page109-125-
dc.relation.journalJOURNAL OF MOLECULAR NEUROSCIENCE-
dc.contributor.googleauthorHan, D-
dc.contributor.googleauthorChoi, MR-
dc.contributor.googleauthorJung, KH-
dc.contributor.googleauthorKim, NS-
dc.contributor.googleauthorKim, SK-
dc.contributor.googleauthorChai, JC-
dc.contributor.googleauthorLee, YS-
dc.contributor.googleauthorChai, YG-
dc.relation.code2015003435-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E]-
dc.sector.departmentDEPARTMENT OF MOLECULAR AND LIFE SCIENCE-
dc.identifier.pidyslee-


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