Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배옥남 | - |
dc.date.accessioned | 2018-02-05T02:11:09Z | - |
dc.date.available | 2018-02-05T02:11:09Z | - |
dc.date.issued | 2015-01 | - |
dc.identifier.citation | KIDNEY & BLOOD PRESSURE RESEARCH, v. 40, No. 1, Page. 1-12 | en_US |
dc.identifier.issn | 1420-4096 | - |
dc.identifier.issn | 1423-0143 | - |
dc.identifier.uri | https://www.karger.com/Article/Abstract/368466 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/35383 | - |
dc.description.abstract | Background/Aims: Drug-induced acute kidney injury (AKI) has been a severe threat to hospitalized patients, raising the urgent needs to develop strategies to reduce AKI. We investigated the protective activity of Dendropanax morbifera (DP), a medicinal plant which has been widely used to treat infectious and pain diseases, on acute kidney injury (AKI) using cisplatin-induced nephropathic models. Methods: Both in vitro renal tubular cells (NRK-52E) and in vivo rat models were used to demonstrate the nephroprotective effect of DP. Results: Methanolic extract from DP significantly reduced cisplatin-induced toxicity in renal tubular cells. Through successive liquid extraction, the extract of DP was separated into n-hexane, CHCl3, EtOAc, n-BuOH, and H2O fractions. Among these, the CHCl3 fraction (DPCF) was found to be most potent. The protective activity of DPCF was found to be mediated through anti-oxidant, mitochondrial protective, and anti-apoptotic activities. In in vivo rat models of AKI, treatment with DPCF significantly reversed the cisplatin-induced increase in blood urea nitrogen and serum creatinine and histopathologic damage, recovered the level of anti-oxidant enzymes, and inhibited renal apoptosis. Conclusion: We demonstrated that DP extracts decreased cisplatin-induced renal toxicity, indicating its potential to ameliorate drug-associated acute kidney damage. | en_US |
dc.description.sponsorship | This work was supported by a grant (No. C0036782) from Business for Cooperative R&D between Industry, Academy, and Research Institute funded Korea Small and Medium Business Administration in 2012, and by a study (No. 2013-A-7184-010203) on the Leaders INdustry-university Cooperation Project supported by the Ministry of Education (MOE), Korea. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | KARGER | en_US |
dc.subject | Nephrotoxicity | en_US |
dc.subject | Cisplatin | en_US |
dc.subject | Acute kidney injury | en_US |
dc.subject | Dendropanax morbifera | en_US |
dc.subject | ACUTE TUBULAR-NECROSIS | en_US |
dc.subject | ANTICOMPLEMENT ACTIVITY | en_US |
dc.subject | INDUCED NEPHROTOXICITY | en_US |
dc.subject | CELL-DEATH | en_US |
dc.subject | MECHANISMS | en_US |
dc.subject | LEVEILLE | en_US |
dc.subject | RATS | en_US |
dc.subject | TRANSPORTERS | en_US |
dc.subject | QUERCETIN | en_US |
dc.subject | TOXICITY | en_US |
dc.title | Protective Activity of Dendropanax Morbifera Against Cisplatin-Induced Acute Kidney Injury | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 40 | - |
dc.identifier.doi | 10.1159/000368466 | - |
dc.relation.page | 1-12 | - |
dc.relation.journal | KIDNEY & BLOOD PRESSURE RESEARCH | - |
dc.contributor.googleauthor | Kim, Eun-Sun | - |
dc.contributor.googleauthor | Lee, Jong Soo | - |
dc.contributor.googleauthor | Akram, Muhammad | - |
dc.contributor.googleauthor | Kim, Kyeong-A | - |
dc.contributor.googleauthor | Shin, Young-Jun | - |
dc.contributor.googleauthor | Yu, Jong-Hyun | - |
dc.contributor.googleauthor | Bae, Ok-Nam | - |
dc.relation.code | 2015002413 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | onbae | - |
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