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dc.contributor.author배옥남-
dc.date.accessioned2018-02-05T02:11:09Z-
dc.date.available2018-02-05T02:11:09Z-
dc.date.issued2015-01-
dc.identifier.citationKIDNEY & BLOOD PRESSURE RESEARCH, v. 40, No. 1, Page. 1-12en_US
dc.identifier.issn1420-4096-
dc.identifier.issn1423-0143-
dc.identifier.urihttps://www.karger.com/Article/Abstract/368466-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/35383-
dc.description.abstractBackground/Aims: Drug-induced acute kidney injury (AKI) has been a severe threat to hospitalized patients, raising the urgent needs to develop strategies to reduce AKI. We investigated the protective activity of Dendropanax morbifera (DP), a medicinal plant which has been widely used to treat infectious and pain diseases, on acute kidney injury (AKI) using cisplatin-induced nephropathic models. Methods: Both in vitro renal tubular cells (NRK-52E) and in vivo rat models were used to demonstrate the nephroprotective effect of DP. Results: Methanolic extract from DP significantly reduced cisplatin-induced toxicity in renal tubular cells. Through successive liquid extraction, the extract of DP was separated into n-hexane, CHCl3, EtOAc, n-BuOH, and H2O fractions. Among these, the CHCl3 fraction (DPCF) was found to be most potent. The protective activity of DPCF was found to be mediated through anti-oxidant, mitochondrial protective, and anti-apoptotic activities. In in vivo rat models of AKI, treatment with DPCF significantly reversed the cisplatin-induced increase in blood urea nitrogen and serum creatinine and histopathologic damage, recovered the level of anti-oxidant enzymes, and inhibited renal apoptosis. Conclusion: We demonstrated that DP extracts decreased cisplatin-induced renal toxicity, indicating its potential to ameliorate drug-associated acute kidney damage.en_US
dc.description.sponsorshipThis work was supported by a grant (No. C0036782) from Business for Cooperative R&D between Industry, Academy, and Research Institute funded Korea Small and Medium Business Administration in 2012, and by a study (No. 2013-A-7184-010203) on the Leaders INdustry-university Cooperation Project supported by the Ministry of Education (MOE), Korea.en_US
dc.language.isoen_USen_US
dc.publisherKARGERen_US
dc.subjectNephrotoxicityen_US
dc.subjectCisplatinen_US
dc.subjectAcute kidney injuryen_US
dc.subjectDendropanax morbiferaen_US
dc.subjectACUTE TUBULAR-NECROSISen_US
dc.subjectANTICOMPLEMENT ACTIVITYen_US
dc.subjectINDUCED NEPHROTOXICITYen_US
dc.subjectCELL-DEATHen_US
dc.subjectMECHANISMSen_US
dc.subjectLEVEILLEen_US
dc.subjectRATSen_US
dc.subjectTRANSPORTERSen_US
dc.subjectQUERCETINen_US
dc.subjectTOXICITYen_US
dc.titleProtective Activity of Dendropanax Morbifera Against Cisplatin-Induced Acute Kidney Injuryen_US
dc.typeArticleen_US
dc.relation.no1-
dc.relation.volume40-
dc.identifier.doi10.1159/000368466-
dc.relation.page1-12-
dc.relation.journalKIDNEY & BLOOD PRESSURE RESEARCH-
dc.contributor.googleauthorKim, Eun-Sun-
dc.contributor.googleauthorLee, Jong Soo-
dc.contributor.googleauthorAkram, Muhammad-
dc.contributor.googleauthorKim, Kyeong-A-
dc.contributor.googleauthorShin, Young-Jun-
dc.contributor.googleauthorYu, Jong-Hyun-
dc.contributor.googleauthorBae, Ok-Nam-
dc.relation.code2015002413-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidonbae-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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