Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 공구 | - |
dc.date.accessioned | 2018-02-03T04:50:16Z | - |
dc.date.available | 2018-02-03T04:50:16Z | - |
dc.date.issued | 2011-03 | - |
dc.identifier.citation | EUROPEAN JOURNAL OF CANCER PREVENTION, v. 20, NO 2, Page. 102-111 | en_US |
dc.identifier.issn | 0959-8278 | - |
dc.identifier.uri | http://ovidsp.tx.ovid.com/sp-3.27.2b/ovidweb.cgi?QS2=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 | - |
dc.description.abstract | Earlier studies have shown that tolfenamic acid (Tol) exhibits anticancer activity in several cancer models by inhibiting tumor growth and angiogenesis. However, the chemopreventive effect of Tol on a cervical cancer model and the underlying mechanism of action are unknown. In this study, Tol was found to inhibit cell proliferation by inducing apoptosis without affecting cyclo-oxygenase 2 expression, but ampiroxicam did not. Tol decreases the specificity protein 1 (Sp1) mRNA and its promoter activity in KB cervical cancer cells, and the downregulation of Sp1 protein by affecting several proteins that contain GC-rich sites on their promoters. Studies using small interference RNA and an Sp1-specific inhibitor (mithramycin A) confirmed that the decrease in Sp1 by Tol affects survivin and p27. Tol also inhibited tumor growth and Sp1 protein in athymic nude mice xenografts. These results show that Tol could be a potent anticervical cancer drug that acts by regulating Sp1 protein and its downstream pathways. European Journal of Cancer Prevention 20: 102-111 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. | en_US |
dc.description.sponsorship | This study was supported by Bio R&D program through the Korea Science and Engineering Foundation (M10870050003-08N7005-00311) and Basic Science Research Program through the National Research Foundation of Korea (2010-0007598) funded by the Ministry of Education, Science and Technology. | en_US |
dc.language.iso | en | en_US |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | en_US |
dc.subject | apoptosis | en_US |
dc.subject | cervical cancer | en_US |
dc.subject | specificity protein 1 | en_US |
dc.subject | tolfenamic acid | en_US |
dc.title | Chemopreventive effect of tolfenamic acid on KB human cervical cancer cells and tumor xenograft by downregulating specificity protein 1 | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 20 | - |
dc.identifier.doi | 10.1097/CEJ.0b013e328341e38f | - |
dc.relation.page | 102-111 | - |
dc.relation.journal | EUROPEAN JOURNAL OF CANCER PREVENTION | - |
dc.contributor.googleauthor | Shim, J.-H. | - |
dc.contributor.googleauthor | Shin, J.-A. | - |
dc.contributor.googleauthor | Jung, J.-Y. | - |
dc.contributor.googleauthor | Choi, K.-H. | - |
dc.contributor.googleauthor | Choi, E.-S. | - |
dc.contributor.googleauthor | Cho, N.-P. | - |
dc.contributor.googleauthor | Kong, G. | - |
dc.contributor.googleauthor | Ryu, M.H. | - |
dc.contributor.googleauthor | Chae, J.-I. | - |
dc.contributor.googleauthor | Cho, S.-D. | - |
dc.relation.code | 2011202995 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | gkong | - |
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