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Chemopreventive effect of tolfenamic acid on KB human cervical cancer cells and tumor xenograft by downregulating specificity protein 1

Title
Chemopreventive effect of tolfenamic acid on KB human cervical cancer cells and tumor xenograft by downregulating specificity protein 1
Author
공구
Keywords
apoptosis; cervical cancer; specificity protein 1; tolfenamic acid
Issue Date
2011-03
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
EUROPEAN JOURNAL OF CANCER PREVENTION, v. 20, NO 2, Page. 102-111
Abstract
Earlier studies have shown that tolfenamic acid (Tol) exhibits anticancer activity in several cancer models by inhibiting tumor growth and angiogenesis. However, the chemopreventive effect of Tol on a cervical cancer model and the underlying mechanism of action are unknown. In this study, Tol was found to inhibit cell proliferation by inducing apoptosis without affecting cyclo-oxygenase 2 expression, but ampiroxicam did not. Tol decreases the specificity protein 1 (Sp1) mRNA and its promoter activity in KB cervical cancer cells, and the downregulation of Sp1 protein by affecting several proteins that contain GC-rich sites on their promoters. Studies using small interference RNA and an Sp1-specific inhibitor (mithramycin A) confirmed that the decrease in Sp1 by Tol affects survivin and p27. Tol also inhibited tumor growth and Sp1 protein in athymic nude mice xenografts. These results show that Tol could be a potent anticervical cancer drug that acts by regulating Sp1 protein and its downstream pathways. European Journal of Cancer Prevention 20: 102-111 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
URI
http://ovidsp.tx.ovid.com/sp-3.27.2b/ovidweb.cgi?QS2=434f4e1a73d37e8cb8a068b15bb89aace67d2f94c7daec13a05568a8a763f6d8e9efe2616ac50a60510bda41a0cdaec4c7cf941c90cc6c3ca176b6045b5fcf0f415eda9a50fc95cde69b37e71df841465dbe6756a700adde46a3d7a241344266fb6958a2df907141af8cfaea33c251577c12ddca7c2b5dc5a154ec727607868d853017563c6237117c7bdc7625dc7e6cffe9cffc0571757c746a93d6837e9ce60103dd3157ee12003f8cb6233d011a1dc429e79b6eac957e79cdc7df97cbb799e3860aecdb96606cbae4f1196ae361095fa8f555046abf215ab8ecffcf08c5b9f0a6f461ae904fdd2ea5ad6d3031ec0a390505ff7ea63b47a5d5734a0b205df9b2a779690712b1b71db01afc89663337
ISSN
0959-8278
DOI
10.1097/CEJ.0b013e328341e38f
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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