Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이현규 | - |
dc.date.accessioned | 2018-02-03T04:45:21Z | - |
dc.date.available | 2018-02-03T04:45:21Z | - |
dc.date.issued | 2011-03 | - |
dc.identifier.citation | CARBOHYDRATE POLYMERS, v. 83, NO 3, Page. 1298-1302 | en_US |
dc.identifier.issn | 0144-8617 | - |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S0144861710007708?via%3Dihub | - |
dc.description.abstract | Polysaccharide extracted from Grifola frondosa was subjected to 2,2,6,6-tetramethyl-1-piperidine oxoammonium ion (TEMPO)-mediated oxidation of which effects on the structural and biological properties of the polysaccharide were investigated as a function of degree of oxidation. Successive oxidation of the polysaccharide was confirmed by (13)C NMR spectroscopy and the molecular weight change of the oxidized polysaccharide was observed, decreasing from 10.6 x 10(5) Da to 7.5 x 10(5) Da by 100% oxidation. The oxidation also caused an increase in the water solubility of the polysaccharide while its viscosity was significantly reduced. In addition, when human fibrosarcoma HT1080 cells were treated with 100% oxidized polysaccharide, their in vitro growth was effectively inhibited. However, the oxidation reduced the activity of superoxide dismutase up to 82% at a concentration of 2.5 mg/mL. Thus, the chemical modification by TEMPO-mediated oxidation was shown to play a significant role in the biological properties of the polysaccharides derived from Grifola frondosa. (C) 2010 Elsevier Ltd. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by Mid-career Researcher Program through NRF grant funded by the MEST (No. 2010-0000446). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCI LTD | en_US |
dc.subject | Grifola frondosa | en_US |
dc.subject | Oxidation | en_US |
dc.subject | Cytotoxic activity | en_US |
dc.subject | Superoxide dismutase activity | en_US |
dc.title | Effect of the degree of oxidation on the physicochemical and biological properties of Grifola frondosa polysaccharides | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 83 | - |
dc.identifier.doi | 10.1016/j.carbpol.2010.09.037 | - |
dc.relation.page | 1298-1302 | - |
dc.relation.journal | CARBOHYDRATE POLYMERS | - |
dc.contributor.googleauthor | Bae, I. Y. | - |
dc.contributor.googleauthor | Kim, H. Y. | - |
dc.contributor.googleauthor | Lee, S. | - |
dc.contributor.googleauthor | Lee, H. G. | - |
dc.relation.code | 2011201694 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF HUMAN ECOLOGY[S] | - |
dc.sector.department | DEPARTMENT OF FOOD & NUTRITION | - |
dc.identifier.pid | hyeonlee | - |
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