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The effects of granulocyte-colony stimulating factor on regeneration in nerve crush injuries in rats

Title
The effects of granulocyte-colony stimulating factor on regeneration in nerve crush injuries in rats
Author
송이선
Keywords
Nerve crush injury; Mechanical nerve injury; Granulocyte-colony stimulating factor; Nerve function; Allodynia
Issue Date
2016-03
Publisher
SPRINGER/PLENUM PUBLISHERS
Citation
NEUROCHEMICAL RESEARCH, v. 41, NO 7, Page. 1645-1650
Abstract
Granulocyte-colony stimulating factor (G-CSF) is widely known to have a neuroprotective effect, but its effects on function and morphology in mechanical nerve injury are not well understood. The aim of this study was to confirm the time course of the functional changes and morphological effects of G-CSF in a rat model of nerve crush injury. Twelve-eight rats were divided into three group: sham-operated control group, G-CSF-treated group, and saline treated group. 2 weeks after the nerve crush injury, G-CSF was injected for 5 days. After 4 weeks, functional tests such as motor nerve conduction velocity (MNCV), mechanical and cold allodynia tests, and morphological studies were performed. G-CSF-treated rats had significantly improved nerve function including MNCV and mechanical and cold allodynia. In addition, G-CSF-treated rats had significantly higher the density of myelinated fibers than saline-treated rats. In conclusion, we found that 100 mu g/kg administration of G-CSF promoted long-term functional recovery in a rat model of nerve crush injury.
URI
https://link.springer.com/article/10.1007%2Fs11064-016-1879-zhttp://hdl.handle.net/20.500.11754/35019
ISSN
0364-3190; 1573-6903
DOI
10.1007/s11064-016-1879-z
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RESEARCH INSTITUTE[S](부설연구소) > ETC
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