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dc.contributor.authorRamakrishna Suresh-
dc.date.accessioned2018-02-01T05:36:01Z-
dc.date.available2018-02-01T05:36:01Z-
dc.date.issued2011-01-
dc.identifier.citationCELLULAR AND MOLECULAR LIFE SCIENCES, Page. 15-26en_US
dc.identifier.issn1420-682X-
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs00018-010-0504-6-
dc.description.abstractIt has become apparent that ubiquitination plays a critical role in cell survival and cell death. In addition, deubiquitinating enzymes (DUBs) have been determined to be highly important regulators of these processes. Cells can be subjected to various stresses and respond in a variety of different ways ranging from activation of survival pathways to the promotion of cell death, which eventually eliminates damaged cells. The regulatory mechanisms of apoptosis depend on the balanced action between ubiquitination and deubiquitination systems. There is a growing recognition that DUBs play essential roles in regulating several binding partners to modulate the process of apoptosis. Thus, the interplay between the timing of DUB activity and the specificity of ubiquitin attachment and removal from its substrates during apoptosis is important to ensure cellular homeostasis. This review discusses the role of a few ubiquitin-specific DUBs that are involved in either promoting or suppressing the process of apoptosis.en_US
dc.language.isoenen_US
dc.publisherBIRKHAUSER VERLAG AGen_US
dc.titleThe role of deubiquitinating enzymes in apoptosisen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s00018-010-0504-6-
dc.relation.page15-26-
dc.relation.journalCELLULAR AND MOLECULAR LIFE SCIENCES-
dc.contributor.googleauthorRamakrishna, S.-
dc.contributor.googleauthorSuresh, B.-
dc.contributor.googleauthorBaek, K. H.-
dc.relation.code2011201750-
dc.sector.campusS-
dc.sector.daehakGraduate School of Biomedical Science & Engineering[S]-
dc.sector.department-
dc.identifier.pidsuri28-
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GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S](의생명공학전문대학원) > ETC
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