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The role of deubiquitinating enzymes in apoptosis

Title
The role of deubiquitinating enzymes in apoptosis
Author
Ramakrishna Suresh
Issue Date
2011-01
Publisher
BIRKHAUSER VERLAG AG
Citation
CELLULAR AND MOLECULAR LIFE SCIENCES, Page. 15-26
Abstract
It has become apparent that ubiquitination plays a critical role in cell survival and cell death. In addition, deubiquitinating enzymes (DUBs) have been determined to be highly important regulators of these processes. Cells can be subjected to various stresses and respond in a variety of different ways ranging from activation of survival pathways to the promotion of cell death, which eventually eliminates damaged cells. The regulatory mechanisms of apoptosis depend on the balanced action between ubiquitination and deubiquitination systems. There is a growing recognition that DUBs play essential roles in regulating several binding partners to modulate the process of apoptosis. Thus, the interplay between the timing of DUB activity and the specificity of ubiquitin attachment and removal from its substrates during apoptosis is important to ensure cellular homeostasis. This review discusses the role of a few ubiquitin-specific DUBs that are involved in either promoting or suppressing the process of apoptosis.
URI
https://link.springer.com/article/10.1007%2Fs00018-010-0504-6
ISSN
1420-682X
DOI
10.1007/s00018-010-0504-6
Appears in Collections:
GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S](의생명공학전문대학원) > ETC
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