Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김현영 | - |
dc.date.accessioned | 2018-02-01T00:21:46Z | - |
dc.date.available | 2018-02-01T00:21:46Z | - |
dc.date.issued | 2011-02 | - |
dc.identifier.citation | 대한신경과학회지, 2011, 29(1), P.16-24 | en_US |
dc.identifier.issn | 1225-7044 | - |
dc.identifier.uri | https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001522968 | - |
dc.description.abstract | Background: No prospective analyses of clinical characteristics and prognostic factors on amyotrophic lateral sclerosis (ALS) have been performed in Korea. Methods: The prognosis of 227 sporadic ALS patient with El-Escorial-compatible criteria were evaluated using the serial Korean Amyotrophic Lateral Sclerosis Functional Rating Scale-revised (K-ALSFRS-R), and the progression rate of K-ALSFRS-R (ΔFS=48-ALSFRS-R at the time of diagnosis). Their clinical characteristics and survival times were also analyzed. The endpoint was defined as either time to death or the tracheostomy state. The effects of individual prognostic factors on disease progression were assessed with the Kaplan-Meier life-table method and multivariate Cox proportional regression analysis. The declining ALSFRS-R curve, epidemiological data, and neuropsychological tests were evaluated. Results: Among 331 motor neuron disease (MND) patients, 227 were finally diagnosed as sporadic ALS. The mean age at onset in 227 sporadic ALS patients was 50.7 years (range 19-76 years). Analysis of sequential ALSFRS-R data revealed that a mean ΔFS of 0.73/month and a high ΔFS score were related with early death or a tracheostomy state. Neuropsychological testing revealed nonmotor symptoms, and especially cognitive impairment, had developed in half of our patients. Conclusions: Our data suggest that ΔFS is valuable parameter for evaluating prognosis and clinical course of ALS patients, and clinical characteristics obtained from this study would be informative data for understanding epidemiology of ALS in Korea. | en_US |
dc.description.sponsorship | 본 연구는 보건복지가족부 보건의료연구개발사업의 지원에의하여 이루어진 것임(과제고유번호: A091049). | en_US |
dc.language.iso | ko_KR | en_US |
dc.publisher | 대한신경과학회 | en_US |
dc.subject | Amyotrophic lateral sclerosis | en_US |
dc.subject | Clinical characteristics | en_US |
dc.subject | Clinical characteristics | en_US |
dc.title | 한국의 근위축측삭경화증: 임상 특징 및 예후 예측 인자 | en_US |
dc.title.alternative | Amyotrophic Lateral Sclerosis in Korea: Clinical Characteristics and Prognostic Factors | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 29 | - |
dc.relation.page | 16-24 | - |
dc.relation.journal | 대한신경과학회지 | - |
dc.contributor.googleauthor | 백원기 | - |
dc.contributor.googleauthor | 박아람 | - |
dc.contributor.googleauthor | 김현영 | - |
dc.contributor.googleauthor | 김승현 | - |
dc.contributor.googleauthor | Baek, Wonki | - |
dc.contributor.googleauthor | Park, Aram | - |
dc.contributor.googleauthor | Kim, Hyun Young | - |
dc.contributor.googleauthor | Kim, Seung Hyun | - |
dc.relation.code | 2012233221 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | hyoungkim1 | - |
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