Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 조삼현 | - |
dc.date.accessioned | 2018-02-01T00:10:42Z | - |
dc.date.available | 2018-02-01T00:10:42Z | - |
dc.date.issued | 2011-02 | - |
dc.identifier.citation | VIROLOGY JOURNAL, v. 8, NO 79, Page. 1-5 | en_US |
dc.identifier.issn | 1743-422x | - |
dc.identifier.uri | https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-8-79 | - |
dc.description.abstract | An outbreak of echovirus 5 (ECV 5) occurred in Korea in 2006, marking the first time this virus had been identified in the country since enterovirus surveillance began in 1993. Using a sample isolated from a young male patient with aseptic meningitis, we performed sequencing of the Korean ECV 5 strain and compared it with a prototype strain (Noyce). At the nucleotide level, the P1 region (85.3%) had the highest identity value; at the amino acid level, the P3 region (98.0%) had the highest identity value. The two strains shared all cleavage sites, with the exception of the VP1/2A site, which was TY/GA in the Noyce strain but TR/GA in the Korean ECV 5 isolate. In Vero cells infected with the Korean ECV 5 isolate, no cytotoxicity was observed in the presence of azidothymidine, acyclovir, amantadine, lamivudine, or ribavirin, when the drugs were administered at a CC(50) value > 100 mu g/mL. Of the five drugs, only amantadine (IC(50): 1 +/- 0.42 mu g/mL, TI: 100) and ribavirin (IC(50): 22 +/- 1.36 mu g/mL, TI: 4.55) had any antiviral activity against the Korean ECV 5 isolate. | en_US |
dc.description.sponsorship | National Institute of Health, South Korea | en_US |
dc.language.iso | en | en_US |
dc.publisher | BIOMED CENTRAL LTD | en_US |
dc.subject | ENTEROVIRUSES | en_US |
dc.subject | VIRUSES | en_US |
dc.subject | CLASSIFICATION | en_US |
dc.subject | RECOMBINATION | en_US |
dc.subject | REPLICATION | en_US |
dc.subject | PLECONARIL | en_US |
dc.subject | EVOLUTION | en_US |
dc.subject | SEQUENCE | en_US |
dc.subject | ASSAY | en_US |
dc.subject | MICE | en_US |
dc.title | Genetic diversity of a Korean echovirus 5 isolate and response of the strain to five antiviral drugs | en_US |
dc.type | Article | en_US |
dc.relation.no | 79 | - |
dc.relation.volume | 8 | - |
dc.identifier.doi | 10.1186/1743-422X-8-79 | - |
dc.relation.page | 1-5 | - |
dc.relation.journal | VIROLOGY JOURNAL | - |
dc.contributor.googleauthor | Choi, Hwajung | - |
dc.contributor.googleauthor | Park, Kwisung | - |
dc.contributor.googleauthor | Baek, Kyoungah | - |
dc.contributor.googleauthor | Lee, Changgyun | - |
dc.contributor.googleauthor | Kim, Donguk | - |
dc.contributor.googleauthor | Song, Jaehyoung | - |
dc.contributor.googleauthor | Cho, SamHyun | - |
dc.contributor.googleauthor | Park, JoonSoo | - |
dc.contributor.googleauthor | Choi, YoungJin | - |
dc.contributor.googleauthor | Kang, Byunghak | - |
dc.relation.code | 2011215800 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | chosh | - |
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