Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 노미나 | - |
dc.date.accessioned | 2018-01-10T02:29:53Z | - |
dc.date.available | 2018-01-10T02:29:53Z | - |
dc.date.issued | 2016-03 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v. 6, Article number 23745, Page. 1-9 | en_US |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://www.nature.com/articles/srep23745 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/34295 | - |
dc.description.abstract | Recent studies showing clear differences in the airway microbiota between healthy and diseased individuals shed light on the importance of the airway microbiota in health. Here, we report the associations of host genetics and lifestyles such as smoking, alcohol consumption, and physical activity with the composition of the sputum microbiota using 16S rRNA gene sequence data generated from 257 sputum samples of Korean twin-family cohort. By estimating the heritability of each microbial taxon, we found that several taxa, including Providencia and Bacteroides, were significantly influenced by host genetic factors. Smoking had the strongest effect on the overall microbial community structure among the tested lifestyle factors. The abundances of Veillonella and Megasphaera were higher in current-smokers, and increased with the pack-year value and the Fagerstrom Test of Nicotine Dependence (FTND) score. In contrast, Haemophilus decreased with the pack-year of smoking and the FTND score. Co-occurrence network analysis showed that the taxa were clustered according to the direction of associations with smoking, and that the taxa influenced by host genetics were found together. These results demonstrate that the relationships among sputum microbial taxa are closely associated with not only smoking but also host genetics. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea (NRF) (NRF-2010-0029113 and NRF-2015R1A2A1A10054078). ML was supported by the Global PhD Fellowship Program (NRF-2011-0007454). | en_US |
dc.language.iso | en | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.subject | INFLAMMATORY-BOWEL-DISEASE | en_US |
dc.subject | CYSTIC-FIBROSIS | en_US |
dc.subject | COMMUNITIES | en_US |
dc.subject | DIVERSITY | en_US |
dc.subject | SAMPLES | en_US |
dc.subject | KOREA | en_US |
dc.subject | TWIN | en_US |
dc.title | Analysis of the association between host genetics, smoking, and sputum microbiota in healthy humans | en_US |
dc.type | Article | en_US |
dc.relation.volume | 6 | - |
dc.identifier.doi | 10.1038/srep23745 | - |
dc.relation.page | 1-9 | - |
dc.relation.journal | SCIENTIFIC REPORTS | - |
dc.contributor.googleauthor | Lim, Mi Young | - |
dc.contributor.googleauthor | Yoon, Hyo Shin | - |
dc.contributor.googleauthor | Rho, Mina | - |
dc.contributor.googleauthor | Sung, Joohon | - |
dc.contributor.googleauthor | Song, Yun-Mi | - |
dc.contributor.googleauthor | Lee, Kayoung | - |
dc.contributor.googleauthor | Ko, GwangPyo | - |
dc.relation.code | 2016012537 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF COMPUTER SCIENCE | - |
dc.identifier.pid | minarho | - |
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