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dc.contributor.author최재훈-
dc.date.accessioned2017-12-13T05:37:28Z-
dc.date.available2017-12-13T05:37:28Z-
dc.date.issued2016-02-
dc.identifier.citationImmune Network, v. 16, NO 1, Page. 26-32en_US
dc.identifier.issn1598-2629-
dc.identifier.issn2092-6685-
dc.identifier.urihttps://synapse.koreamed.org/DOIx.php?id=10.4110/in.2016.16.1.26-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/34117-
dc.description.abstractAortic valve stenosis is a heart disease prevalent in the elderly characterized by valvular calcification, fibrosis, and inflammation, but its exact pathogenesis remains unclear. Previously, aortic valve stenosis was thought to be caused by chronic passive and degenerative changes associated with aging. However, recent studies have demonstrated that atherosclerotic processes and inflammation can induce valvular calcification and bone deposition, leading to valvular stenosis. In particular, the most abundant cell type in cardiac valves, valvular interstitial cells, can differentiate into myofibroblasts and osteoblast-like cells, leading to valvular calcification and stenosis. Differentiation of valvular interstitial cells can be trigged by inflammatory stimuli from several immune cell types, including macrophages, dendritic cells, T cells, B cells, and mast cells. This review indicates that crosstalk between immune cells and valvular interstitial cells plays an important role in the development of aortic valve stenosis.en_US
dc.description.sponsorshipThis work was supported by the research fund of Hanyang University (HY-2012-N).en_US
dc.language.isoenen_US
dc.publisher대한면역학회en_US
dc.subjectValveen_US
dc.subjectStenosisen_US
dc.subjectVICen_US
dc.subjectVECen_US
dc.subjectImmune cellsen_US
dc.titleInvolvement of Immune Cell Network in Aortic Valve Stenosis: Communication between Valvular Interstitial Cells and Immune Cellsen_US
dc.typeArticleen_US
dc.relation.no1-
dc.relation.volume16-
dc.identifier.doi10.4110/in.2016.16.1.26-
dc.relation.page26-32-
dc.relation.journalImmune Network-
dc.contributor.googleauthorLee, Seung Hyun-
dc.contributor.googleauthorChoi, Jae-Hoon-
dc.relation.code2016018947-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF NATURAL SCIENCES[S]-
dc.sector.departmentDEPARTMENT OF LIFE SCIENCE-
dc.identifier.pidjchoi75-
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COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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