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dc.contributor.authorKUTZNER, ARNE HOLGER-
dc.date.accessioned2017-12-13T01:35:09Z-
dc.date.available2017-12-13T01:35:09Z-
dc.date.issued2016-02-
dc.identifier.citationCANCER INVESTIGATION, v. 34, NO 2, Page. 64-69en_US
dc.identifier.issn0735-7907-
dc.identifier.issn1532-4192-
dc.identifier.urihttp://www.tandfonline.com/doi/full/10.3109/07357907.2015.1088949-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/34101-
dc.description.abstractRAS protein is a small G protein linked to multiple G protein-coupled receptor (GPCR) signaling cascades and is responsible for various types of cancer, but to this day, Ras is considered "undruggable." Multiple alternative regulators of G protein signaling (RGS) pathways have become the focus of ongoing efforts to identify new cancer therapeutics. We analyzed human cancer genome datasets and describe p60TRP, a recently identified GPCR-associated sorting protein (GPRASP), and its role in various types of cancer. We found that some regions of p60TRP were more prone to specific mutations, with two hotspots for mutations at E15 and E171.en_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS INCen_US
dc.subjectRasen_US
dc.subjectCanceren_US
dc.subjectGPRASPen_US
dc.subjectp60TRPen_US
dc.subjectRanen_US
dc.subjectBHLHB9en_US
dc.subjectGASPen_US
dc.titleGlutamate E15 and E171 are Hotspots in p60TRP-Related Canceren_US
dc.typeArticleen_US
dc.relation.no2-
dc.relation.volume34-
dc.identifier.doi10.3109/07357907.2015.1088949-
dc.relation.page64-69-
dc.relation.journalCANCER INVESTIGATION-
dc.contributor.googleauthorKutzner, Arne-
dc.contributor.googleauthorHeese, Klaus-
dc.relation.code2016002753-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDEPARTMENT OF INFORMATION SYSTEMS-
dc.identifier.pidkutzner-
dc.identifier.orcidhttp://orcid.org/0000-0001-5061-6936-
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COLLEGE OF ENGINEERING[S](공과대학) > INFORMATION SYSTEMS(정보시스템학과) > Articles
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