Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 손현 | - |
dc.contributor.author | 왕성은 | - |
dc.date.accessioned | 2017-11-29T02:30:55Z | - |
dc.date.available | 2017-11-29T02:30:55Z | - |
dc.date.issued | 2017-08 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/33834 | - |
dc.identifier.uri | http://hanyang.dcollection.net/common/orgView/200000430968 | en_US |
dc.description.abstract | Transient receptor potential vanilloid 1 (TRPV1), a nonselective cation channel mainly involved in pain sensation, affects mood and neuroplasticity in the brain, where its role is still poorly understood. Here I show that Trpv1-deficient (Trpv1-/-) mice have an antidepressant-like phenotype following chronic unpredictable stress and basal hippocampal neurogenesis is enhanced. I also found that glucocorticoid receptor (GR)-mediated histone deacetylase (HDAC) 2 expression and activity are reduced in the Trpv1-/- mice. At the same time, levels of p16 and p21, which are implicated in the cell-cycle, are reduced, while levels of neuroplasticity-related molecules are elevated through HDAC2. Hippocampal knockdown of TRPV1 had similar effects both at the behavioral and molecular levels and its antidepressant-like behavioral effects are blocked by HDAC2 overexpression. Furthermore, I found that capsaicin (8-methyl-N-vanillyl-trans-6-nonenamide) treatment resulted in upregulation of HDAC2 in the mouse hippocampus, and HDAC2 was enriched at the promoters of synaptic plasticity-related genes. Collectively, these findings define a novel pathway involving an important role for TRPV1 in chromatin regulation in the adult brain. This pathway provides a molecular link between TRPV1 activity and depression. | - |
dc.publisher | 한양대학교 | - |
dc.title | HDAC2를 매개로 하는 TRPV1의 스트레스 반응 조절 기전 | - |
dc.title.alternative | TRPV1 regulates stress responses through HDAC2 | - |
dc.type | Theses | - |
dc.contributor.googleauthor | 왕성은 | - |
dc.sector.campus | S | - |
dc.sector.daehak | 의생명공학전문대학원 | - |
dc.sector.department | 의생명과학과 | - |
dc.description.degree | Doctor | - |
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