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Total Synthesis of Alkaloid Natural Products Starting with 3,5-Dibromo-2-pyrone as a Useful Building Block

Title
Total Synthesis of Alkaloid Natural Products Starting with 3,5-Dibromo-2-pyrone as a Useful Building Block
Other Titles
유용한 빌딩 블록으로써 출발물질인 3,5-다이브로모파이론을 통한 천연물의 전합성: 에리스리나 알칼로이드의 전합성
Author
송지영
Alternative Author(s)
Jiyoung Song
Advisor(s)
조천규
Issue Date
2017-08
Publisher
한양대학교
Degree
Doctor
Abstract
Erythrina alkaloids in the pea famliy widely distributed in the vegetable field consist of about 70 kinds of natural products and have interesting azatetracyclic structures (A, B, C, D) in common. They represent an attractive synthetic target substance for pharmacological effects including sedation, hypotension, neuromuscular blockade, and CNS activity. An erythrina alkaloid [(±)-Erysotramidine, (±)-Erysotrine, (±)-Erythramine, (±)-Erythraline] was synthesized to further expand the 2-pyrone strategy for target-directed synthesis. Here we report the strategic use of our 3,5-dibromo-2-pyrone and Diels-Alder reactions for the total synthesis of erythrina alkaloids.
URI
http://hdl.handle.net/20.500.11754/33727http://hanyang.dcollection.net/common/orgView/200000431098
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > THEATER & FILM(연극영화학과) > Theses (Master)
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