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Studies towards asymmetric total synthesis of bioactive natural product via regioselective Fischer indolization: (-)-tabersonine

Title
Studies towards asymmetric total synthesis of bioactive natural product via regioselective Fischer indolization: (-)-tabersonine
Other Titles
위치선택적 피셔-인돌화 반응을 통한 생리활성 천연물의 비대칭 전합성에 대한 연구: (-)-tabersonine
Author
설창헌
Alternative Author(s)
Suhl, Chang Heon
Advisor(s)
조천규
Issue Date
2017-08
Publisher
한양대학교
Degree
Master
Abstract
Recently we have demonstrated that ene-hydrazide is readily available from enol triflate in regiochemically defined form, which may undergo Fischer indolization reaction with no regiochemical scrambling. In order to prove its usefulness, we then started to apply our new method to the synthesis of various aspidosperma alkaloids. Prior to syntheses of a variety of intricate aspidosperma alkaloids, we initiated synthesis of (-)-tabersonine. Regioselective Fischer indolization under Lewis acid condition led us to be close to the total synthesis of (-)-tabersonine. Presented herein are the results so far of total synthesis of (-)-tabersonine.
URI
http://hdl.handle.net/20.500.11754/33726http://hanyang.dcollection.net/common/orgView/200000431068
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > THEATER & FILM(연극영화학과) > Theses (Ph.D.)
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