녹내장 안약을 사용하는 초기 중년 환자에서 마이봄샘기능장애와 관련된 눈꺼풀변화

Abstract

Purpose The purpose of this study is to investigate the relationship between topical glaucoma medications and meibomian gland dysfunction (MGD) in early middle-aged patients with glaucoma. Methods Fifty patients with glaucoma under the age of 50 who used topical glaucoma medications for more than 6 months and forty normal control subjects of similar age were included. Each group was graded from 0 to 4 by evaluating MGD under slit lamp microscopy. Tear film break-up time (BUT), ocular surface staining and Marx line scores were evaluated. The difference between the two groups was analyzed statistically. Results The prevalence of MGD was 82% in the group using topical glaucoma medications and 52.5% in the control group. The average period using topical glaucoma medications was 27.4 months. There was a significant difference in BUT and Marx line score according to MGD. There was no significant correlation between the duration of topical glaucoma medications use and the severity of MGD, but the degree MGD and Marx line score were significantly correlated. Conclusion The glaucoma eye drops may be a factor affecting the eyelid changes associated with MGD. Marx line score may be used as an index to evaluate MGD in patients with glaucoma.