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Nanoscale diameter control of sensory polydiacetylene nanoparticles on microfluidic chip for enhanced fluorescence signal

Title
Nanoscale diameter control of sensory polydiacetylene nanoparticles on microfluidic chip for enhanced fluorescence signal
Author
김종만
Keywords
Polydiacetylene nanoparticles sensor; Synthesis; Micromixer; Size-control; Fluorescence-control
Issue Date
2016-02
Publisher
ELSEVIER SCIENCE SA
Citation
SENSORS AND ACTUATORS B-CHEMICAL, v. 230, Page. 623-629
Abstract
Owing to its stimulus-induced fluorescence 'turn-on' feature, polydiacetylene (PDA) has been actively investigated as a label-free sensor matrix. Fabrication of monodisperse PDA particles is important for the efficiency of microarray or microfluidic-based PDA sensor chips. Conventional bulk methods inevitably produce polydisperse mixtures of PDA nanoparticles. Herein we report the synthesis of size-controlled PDA nanoparticles on a microfluidic chip using a staggered herringbone micromixer (SHM), a well-known chaotic mixer. PDA particles of diameters ranging from 36 to 84 nm were readily prepared by adjusting the flow conditions. In addition, use of the SHM method remarkably increased the productivity of the PDA nanoparticles, by about 40 times relative to PDA nanoparticles prepared by means of a hydrodynamic focusing method. The fluorescence intensity of the PDA nanoparticles was found to be dependent upon their size distribution, and a microfluidic channel containing smaller PDA particles was found to emit stronger fluorescence than one containing larger PDA particles. (C) 2016 Elsevier B.V. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S0925400516302143?via%3Dihubhttp://hdl.handle.net/20.500.11754/31884
ISSN
0925-4005
DOI
10.1016/j.snb.2016.02.065
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > CHEMICAL ENGINEERING(화학공학과) > Articles
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