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Overview of IgG4-related tubulointerstitial nephritis and its mimickers

Title
Overview of IgG4-related tubulointerstitial nephritis and its mimickers
Author
신수진
Keywords
IgG4-related disease; Lupus nephritis; Sjogren's syndrome; Anti-neutrophil cytoplasmic antibody-associated vasculitis; Glomerulonephritis, membranous
Issue Date
2016-01
Publisher
Korean Society of Pathologists
Citation
Journal of Pathology and Translational Medicine, v. 50, NO 1, Page. 26-36
Abstract
Tubulointerstitial nephritis (TIN) is the most common form of renal involvement in IgG4-related disease. It is characterized by a dominant infiltrate of IgG4-positive plasma cells in the interstitium and storiform fibrosis. Demonstration of IgG4-positive plasma cells is essential for diagnosis, but the number of IgG4-positive cells and the ratio of IgG4-positive/IgG-positive plasma cells may vary from case to case and depending on the methods of tissue sampling even in the same case. IgG4-positive plasma cells can be seen in TIN associated with systemic lupus erythematosus, Sjögren syndrome, or anti-neutrophil cytoplasmic antibody-associated vasculitis, which further add diagnostic confusion and difficulties. To have a more clear view of IgG4-TIN and to delineate differential points from other TIN with IgG4-positive plasma cell infiltrates, clinical and histological features of IgG4-TIN and its mimickers were reviewed. In the rear part, cases suggesting overlap of IgG4-TIN and its mimickers and glomerulonephritis associated with IgG4-TIN were briefly described.
URI
http://jpatholtm.org/journal/view.php?doi=10.4132/jptm.2015.11.09http://hdl.handle.net/20.500.11754/31737
ISSN
2383-7837; 2383-7845
DOI
10.4132/jptm.2015.11.09
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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