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Surface Functionalized Graphene Biosensor on Sapphire for Cancer Cell Detection

Title
Surface Functionalized Graphene Biosensor on Sapphire for Cancer Cell Detection
Author
이조원
Keywords
Biosensors; Graphene; 2D; Cell Detection; CVD
Issue Date
2016-01
Publisher
AMER SCIENTIFIC PUBLISHERS
Citation
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v. 16, NO 1, Page. 144-151
Abstract
Graphene has several unique physical, optical and electrical properties such as a two-dimensional (2D) planar structure, high optical transparency and high carrier mobility at room temperature. These make graphene interesting for electrical biosensing. Using a catalyst-free chemical vapor deposition (CVD) method, graphene film is grown on a sapphire substrate. There is a single or a few sheets as confirmed by Raman spectroscopy and atomic force microscopy (AFM). Electrical graphene biosensors are fabricated to detect large-sized biological analytes such as cancer cells. Human colorectal carcinoma cells are sensed by the resistance change of an active bio-functionalized graphene device as the cells are captured by the immobilized antibody surface. The functionalized sensors show an increase in resistance as large as similar to 20% of the baseline with a small number of adhered cells. This study suggests that the bio-functionalized electrical graphene sensors on sapphire, which is a highly transparent material, can potentially detect circulating tumor cells (CTCs) and monitor cellular electrical behavior while being compatible with fluorescence-based optical detection bioassays.
URI
http://www.ingentaconnect.com/content/asp/jnn/2016/00000016/00000001/art00010http://hdl.handle.net/20.500.11754/31701
ISSN
1533-4880; 1533-4899
DOI
10.1166/jnn.2016.12042
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > CONVERGENCE NANOSCIENCE(나노융합과학과) > Articles
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