Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이종민 | - |
dc.date.accessioned | 2017-11-17T00:21:58Z | - |
dc.date.available | 2017-11-17T00:21:58Z | - |
dc.date.issued | 2016-01 | - |
dc.identifier.citation | JOURNAL OF ALZHEIMERS DISEASE, v. 50, NO 3, Page. 709-718 | en_US |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.issn | 1875-8908 | - |
dc.identifier.uri | https://content.iospress.com/articles/journal-of-alzheimers-disease/jad150637 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/31470 | - |
dc.description.abstract | Background: Recent advances in resting-state functional MRI have revealed altered functional networks in Alzheimer's disease (AD), especially those of the default mode network (DMN) and central executive network (CEN). However, few studies have evaluated whether small vessel disease (SVD) or combined amyloid and SVD burdens affect the DMN or CEN. Objective: The aim of this study was to evaluate whether SVD or combined amyloid and SVD burdens affect the DMN or CEN. Methods: In this cross-sectional study, we investigated the resting-state functional connectivity within DMN and CEN in 37 Pittsburgh compound-B (PiB)(+) AD, 37 PiB(-) subcortical vascular dementia (SVaD), 13 mixed dementia patients, and 65 normal controls. Results: When the resting-stateDMNof PiB(+) AD and PiB(-) SVaD patients were compared, the PiB(+) AD patients displayed lower functional connectivity in the inferior parietal lobule while the PiB(-) SVaDpatients displayed lower functional connectivity in the medial frontal and superior frontal gyri. Compared to the PiB(-) SVaD or PiB(+) AD, the mixed dementia patients displayed lower functional connectivity within the DMN in the posterior cingulate gyrus. When the resting- state CEN connectivity of PiB(+) AD and PiB(-) SVaD patients were compared, the PiB(-) SVaD patients displayed lower functional connectivity in the anterior insular region. Compared to the PiB(-) SVaD or PiB(+) AD, the mixed dementia patients displayed lower functional connectivity within the CEN in the inferior frontal gyrus. Conclusions: Our findings suggest that in PiB(+) AD and PiB(-) SVaD, there is divergent disruptions in resting-state DMN and CEN. Furthermore, patients with combined amyloid and SVD burdens exhibited more disrupted resting- state DMN and CEN than patients with only amyloid or SVD burden. | en_US |
dc.description.sponsorship | This study was supported by Basic Research Program through the National Research Foundation of South Korea (NRF) funded by the Ministry of Education (NRF-2013R1A1A2065365), the Korean Healthcare Technology R&D Project, Ministry for Health and Welfare Affairs (HIC120713), a Korean Science and Engineering Foundation (KOSEF) NRL program grant funded by the Korean government (MEST; 20110028333), a Samsung Medical Center Clinical Research Development Program grant (CRL108011 & CRS 110-14-1), the Korea Ministry of Environment (MOE) as the Environmental Health Action Program (2014001360002), the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare, Republic of Korea (HI14C2768), and the National Research Foundation of Korea (NRF) grant funded by the Korea government(MSIP) (NRF-2015R1C1A2A01053281) | en_US |
dc.language.iso | en | en_US |
dc.publisher | IOS PRESS | en_US |
dc.subject | Alzheimer's disease | en_US |
dc.subject | amyloid | en_US |
dc.subject | central executive network | en_US |
dc.subject | default mode network | en_US |
dc.subject | resting-state functional MRI | en_US |
dc.subject | small vessel disease | en_US |
dc.subject | subcortical vascular dementia | en_US |
dc.title | Distinctive Resting State Network Disruptions Among Alzheimer's Disease, Subcortical Vascular Dementia, and Mixed Dementia Patients | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 50 | - |
dc.identifier.doi | 10.3233/JAD-150637 | - |
dc.relation.page | 709-718 | - |
dc.relation.journal | JOURNAL OF ALZHEIMERS DISEASE | - |
dc.contributor.googleauthor | Kim, Hee Jin | - |
dc.contributor.googleauthor | Cha, Jungho | - |
dc.contributor.googleauthor | Lee, Jong-Min | - |
dc.contributor.googleauthor | Shin, Ji Soo | - |
dc.contributor.googleauthor | Jung, Na-Yeon | - |
dc.contributor.googleauthor | Kim, Yeo Jin | - |
dc.contributor.googleauthor | Choe, Yearn Seong | - |
dc.contributor.googleauthor | Lee, Kyung Han | - |
dc.contributor.googleauthor | Kim, Sung Tae | - |
dc.contributor.googleauthor | Kim, Jae Seung | - |
dc.relation.code | 2016009110 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DIVISION OF ELECTRICAL AND BIOMEDICAL ENGINEERING | - |
dc.identifier.pid | ljm | - |
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