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dc.contributor.author이종민-
dc.date.accessioned2017-11-17T00:15:49Z-
dc.date.available2017-11-17T00:15:49Z-
dc.date.issued2016-01-
dc.identifier.citationEUROPEAN JOURNAL OF PAIN, v. 20, NO 1, Page. 92-105en_US
dc.identifier.issn1090-3801-
dc.identifier.issn1532-2149-
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1002/ejp.696/abstract-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/31468-
dc.description.abstractBackgroundAlthough the exact mechanism of TENS pain relief is unknown, it is believed that TENS impulses interrupt nociceptive signals at the dorsal horn of the spinal cord. AimsTo evaluate the hypotheses that during pain caused by noxious stimuli, brain responses, temporal summation and brain functional connectivity are modulated by TENS, and that mechanisms of pain relief by TENS differ between men and women. MethodsDuring fMRI scanning, the same noxious stimuli were delivered to each participant in pain-only and pain+TENS conditions. In the pain-only condition, noxious stimuli were presented without TENS. In the pain+TENS condition, participants received noxious stimuli and TENS concurrently. Participants were initially presented with TENS at an intensity that was just below that causing discomfort. TENS intensity was presented in a step-wise fashion to prevent temporal summation from repetitive noxious stimuli. ResultsPain and unpleasantness ratings were significantly higher in the pain-only than the pain+TENS condition. With non-painful TENS, primary and secondary somatosensory and parietal cortices were activated, and temporal summation from repetitive noxious stimuli was prevented. Periaqueductal gray (PAG) and lateral prefrontal cortex functional connectivity was increased by TENS, and modulated by testosterone and cortisol. Women reported greater pain during TENS than men, and showed greater activation in the temporoparietal junction cortex and increased PAG functional connectivity with the orbitofrontal cortex. ConclusionTENS led to pain reduction, probably due to activation of the descending pain-inhibitory pathway, indicating that this TENS method may be applied in clinical practice.en_US
dc.description.sponsorshipThis study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (*2015R1D1A1A09059766, 2012R1A1A2004868), and by a grant from the Korean Health Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A092125).en_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.subjectDORSOLATERAL PREFRONTAL CORTEXen_US
dc.subjectMIDBRAIN PERIAQUEDUCTAL GRAYen_US
dc.subjectPOSTOPERATIVE PAINen_US
dc.subjectCONTROLLED-TRIALen_US
dc.subjectSEX-DIFFERENCESen_US
dc.subjectMEDIAN NERVEen_US
dc.subjectDOUBLE-BLINDen_US
dc.subjectPERCEPTIONen_US
dc.subjectMODULATIONen_US
dc.subjectANALGESIAen_US
dc.titleBrain mechanisms of pain relief by transcutaneous electrical nerve stimulation: A functional magnetic resonance imaging studyen_US
dc.typeArticleen_US
dc.relation.no1-
dc.relation.volume20-
dc.identifier.doi10.1002/ejp.696-
dc.relation.page92-105-
dc.relation.journalEUROPEAN JOURNAL OF PAIN-
dc.contributor.googleauthorChoi, J. C.-
dc.contributor.googleauthorKim, J.-
dc.contributor.googleauthorKang, E.-
dc.contributor.googleauthorLee, J. -M.-
dc.contributor.googleauthorCha, J.-
dc.contributor.googleauthorKim, Y. J.-
dc.contributor.googleauthorLee, H. G.-
dc.contributor.googleauthorChoi, J. -H.-
dc.contributor.googleauthorYi, D. -J.-
dc.relation.code2016010406-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDIVISION OF ELECTRICAL AND BIOMEDICAL ENGINEERING-
dc.identifier.pidljm-
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COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
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