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The neural correlates of motor intentional disorders in patients with subcortical vascular cognitive impairment

Title
The neural correlates of motor intentional disorders in patients with subcortical vascular cognitive impairment
Author
이종민
Keywords
Motor intentional disorder; Subcortical vascular cognitive impairment; Cortical thickness; Tract-based spatial statistics
Issue Date
2016-01
Publisher
SPRINGER HEIDELBERG
Citation
JOURNAL OF NEUROLOGY, v. 263, NO 1, Page. 89-99
Abstract
Subcortical vascular cognitive impairment (SVCI) refers to cognitive impairment associated with small vessel disease. Motor intentional disorders (MID) have been reported in patients with SVCI. However, there are no studies exploring the neuroanatomical regions related to MID in SVCI patients. The aim of this study, therefore, was to investigate the neural correlates of MID in SVCI patients. Thirty-one patients with SVCI as well as 10 healthy match control participants were included. A "Pinch-Grip" apparatus was used to quantify the force control capabilities of the index finger in four different movement phases including initiation, development, maintenance, and termination. All participants underwent magnetic resonance imaging (MRI). Topographical cortical areas and white matter tracts correlated with the performances of the four different movement phases were assessed by the surface-based morphometry and tract-based spatial statistics analyses. Poorer performance in the maintenance task was related to cortical thinning in bilateral dorsolateral prefrontal, orbitofrontal and parietal cortices, while poorer performance in the termination task was associated with the disruption of fronto-parietal cortical areas as well as the white matter tracts including splenium and association fibers such as superior longitudinal fasciculus. Our study demonstrates that cortical areas and underlying white matter tracts associated with fronto-parietal attentional system play an important role in motor impersistence and perseveration in SVCI patients.
URI
https://link.springer.com/article/10.1007%2Fs00415-015-7946-6http://hdl.handle.net/20.500.11754/31467
ISSN
0340-5354; 1432-1459
DOI
10.1007/s00415-015-7946-6
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
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