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Impact of smoking on neurodegeneration and cerebrovascular disease markers in cognitively normal men

Title
Impact of smoking on neurodegeneration and cerebrovascular disease markers in cognitively normal men
Author
이종민
Keywords
Alzheimer's disease; cerebrovascular disease; cortical thickness; dementia; lacunes; neurodegeneration; smoking; white matter hyperintensities
Issue Date
2016-01
Publisher
WILEY-BLACKWELL
Citation
EUROPEAN JOURNAL OF NEUROLOGY, v. 23, NO 1, Page. 110-119
Abstract
Background and purpose: Smoking is a major risk factor for cognitive decline and dementia. However, the exact pathobiology of smoking remains unknown. The effects of smoking on cortical thickness as a biomarker of neurodegeneration or white matter hyperintensities and lacunes as biomarkers of cerebrovascular burden were concurrently evaluated. Methods: Our study included 977 cognitively normal men who visited a health promotion centre and underwent medical check-ups, including 3.0 T magnetic resonance imaging. Participants were categorized into never smoker, past smoker or current smoker groups and pack-years and the years of smoking cessation were used as continuous variables. Results: The current smoker group exhibited cortical thinning in frontal and temporo-parietal regions compared with the never smoker group. These effects were particularly prominent in smokers with a high cumulative exposure to smoking in the current smoker group. However, there was no association between smoking and the severity of white matter hyperintensity or number of lacunes. Conclusion: Our findings indicate that smoking might impact on neurodegeneration rather than cerebrovascular burdens in cognitively normal men, suggesting that smoking might be an important modifiable risk factor for the development of Alzheimer's disease.
URI
http://onlinelibrary.wiley.com/doi/10.1111/ene.12816/abstracthttp://hdl.handle.net/20.500.11754/31466
ISSN
1351-5101; 1468-1331
DOI
10.1111/ene.12816
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
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